(Q45300712)

11 December 2017

title

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease? (English)

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11 December 2017

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M S Goldberg

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11 December 2017

P T Lansbury

series ordinal

2

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11 December 2017

language of work or name

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1 July 2000

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11 December 2017

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11 December 2017

volume

2

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11 December 2017

issue

7

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11 December 2017

page(s)

E115-9

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Prospects for new restorative and neuroprotective treatments in Parkinson's disease

11 December 2017

cites work

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7 January 2021

New animal models for Parkinson's disease

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7 January 2021

Neuropathology of Parkinson's disease

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7 January 2021

Dementia with Lewy bodies

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7 January 2021

Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

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7 January 2021

Structural neurology: are seeds at the root of neuronal degeneration?

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7 January 2021

Parkinson disease in twins: an etiologic study

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7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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7 January 2021

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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7 January 2021

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

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7 January 2021

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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7 January 2021

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

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7 January 2021

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

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7 January 2021

Molecular neurobiology--a conference sponsored by the NIMH.

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7 January 2021

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

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7 January 2021

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

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7 January 2021

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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7 January 2021

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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7 January 2021

A Drosophila model of Parkinson's disease

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7 January 2021

Amyloid fibrillogenesis: themes and variations

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7 January 2021

Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein

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7 January 2021

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

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7 January 2021

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease

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7 January 2021

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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7 January 2021

Contribution of somal Lewy bodies to neuronal death

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7 January 2021

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

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7 January 2021

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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7 January 2021

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

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7 January 2021

Genetic suppression of polyglutamine toxicity in Drosophila

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7 January 2021

The ubiquitin pathway in Parkinson's disease

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7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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7 January 2021

Implications of macromolecular crowding for protein assembly.

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7 January 2021

Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats

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7 January 2021

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

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7 January 2021

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

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7 January 2021

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

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7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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7 January 2021

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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7 January 2021

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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7 January 2021

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

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7 January 2021

Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

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7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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7 January 2021

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

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7 January 2021

Identifiers

DOI

10.1038/35017124

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Dimensions Publication ID

11 December 2017

1037071406

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