(Q4459741)

http://www.ebi.ac.uk/interpro/protein/Q15399

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15399

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15399

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

Toll-like receptor 2 binding

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

17 October 2017

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

protein binding

3 references

8 April 2019

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

8 April 2019

Isolated Toll-like receptor transmembrane domains are capable of oligomerization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

8 April 2019

Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

protein heterodimerization activity

1 reference

8 April 2019

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

lipopeptide binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

transmembrane signaling receptor activity

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

17 October 2017

Toll-like receptor 2 binding

signaling receptor activity

1 reference

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

identical protein binding

1 reference

8 April 2019

Isolated Toll-like receptor transmembrane domains are capable of oligomerization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

phagocytic vesicle membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

1 reference

8 April 2019

plasma membrane

Toll-like receptor 1-Toll-like receptor 2 protein complex

1 reference

17 October 2017

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

integral component of plasma membrane

1 reference

17 October 2017

A family of human receptors structurally related to Drosophila Toll

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

1 reference

8 April 2019

Toll-like receptor 1-Toll-like receptor 2 protein complex

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

toll-like receptor TLR1:TLR2 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

1 reference

8 April 2019

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

1 reference

8 April 2019

cellular response to triacyl bacterial lipopeptide

toll-like receptor 1 signaling pathway

2 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

1 reference

8 April 2019

signal transduction

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

8 April 2019

A family of human receptors structurally related to Drosophila Toll

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

8 April 2019

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

1 reference

8 April 2019

defense response to bacterium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

1 reference

17 October 2017

cell activation

1 reference

8 April 2019

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

immune response

1 reference

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

positive regulation of toll-like receptor 2 signaling pathway

IGI

1 reference

8 April 2019

TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

cellular response to triacyl bacterial lipopeptide

IGI

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

8 April 2019

Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399