(Q44224219)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12444544%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis (English)

1 reference

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15 December 2019

4

1 reference

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15 December 2019

author name string

Matthew B Wilson

1

1 reference

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15 December 2019

Steven J Schreiner

2

1 reference

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15 December 2019

Hyun-Jung Choi

3

1 reference

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15 December 2019

Thomas E Smithgall

5

1 reference

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15 December 2019

language of work or name

English

0 references

publication date

1 November 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12444544%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

number of pages

14

1 reference

inferred from page(s)

published in

Oncogene

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12444544%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

volume

21

1 reference

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15 December 2019

issue

53

1 reference

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15 December 2019

page(s)

8075-8088

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12444544%20AND%20SRC:MED&resulttype=core&format=json

Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

15 December 2019

cites work

1 reference

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7 January 2021

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

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High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance

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SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

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7 January 2021

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

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7 January 2021

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

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7 January 2021

STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells

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7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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7 January 2021

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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7 January 2021

Crk family adaptors-signalling complex formation and biological roles

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7 January 2021

c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis

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7 January 2021

Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571

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7 January 2021

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

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7 January 2021

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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7 January 2021

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

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7 January 2021

Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells

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7 January 2021

Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

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7 January 2021

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin

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7 January 2021

Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia

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7 January 2021

Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras, Rac, and Cdc42 and induces extracellular signal-regulated and c-Jun N-terminal kinase activation

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7 January 2021

Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck

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7 January 2021

Structural basis for selective inhibition of Src family kinases by PP1

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7 January 2021

A multipotential leukemia cell line (K-562) of human origin

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7 January 2021

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc

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7 January 2021

HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression

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7 January 2021

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

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7 January 2021

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome

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7 January 2021

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

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7 January 2021

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

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7 January 2021

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

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7 January 2021

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

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7 January 2021

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

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7 January 2021

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation

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7 January 2021

Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop

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7 January 2021

Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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7 January 2021

Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells

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7 January 2021

Chronic myeloid leukemia

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7 January 2021

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene

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7 January 2021

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

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7 January 2021

The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene

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7 January 2021

Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein

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7 January 2021

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

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7 January 2021

The Src Family Kinase Hck Interacts with Bcr-Abl by a Kinase-independent Mechanism and Phosphorylates the Grb2-binding Site of Bcr

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7 January 2021

Molecular pathogenesis of chronic myeloid leukemia: implications for new therapeutic strategies

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7 January 2021

Role of ERK activation in growth and erythroid differentiation of K562 cells

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7 January 2021