Wikidata

(Q416481)

English

Nucleotide binding oligomerization domain containing 2

mammalian protein found in Homo sapiens

  • Nod2 Signaling Adaptor Protein
  • caspase recruitment domain family, member 15
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
  • NOD2
  • caspase recruitment domain protein 15
  • caspase recruitment domain-containing protein 15
  • NOD-like receptor C2
  • nucleotide-binding oligomerization domain-containing protein 2
  • nucleotide-binding oligomerization domain 2
  • NLR family, CARD domain containing 2
  • inflammatory bowel disease protein 1
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No label defined

No description defined

Statements

image
NOD2 protein.png
1,920 × 975; 597 KB
0 references
molecular function
protein binding
determination method or standard
IPI
20 references
retrieved
1 January 2018
stated in
CLAN, a novel human CED-4-like gene
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
Role for erbin in bacterial activation of Nod2
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
Endosomes are specialized platforms for bacterial sensing and NOD2 signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
The intermediate filament protein, vimentin, is a regulator of NOD2 activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
retrieved
1 January 2018
stated in
Evaluation of Nod-like receptor (NLR) effector domain interactions
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IPI
cell component
cytoplasm
determination method or standard
IDA
TAS
IEA
6 references
retrieved
16 July 2018
stated in
NLRs join TLRs as innate sensors of pathogens
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29
determination method or standard
TAS
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29
determination method or standard
IEA
retrieved
16 July 2018
stated in
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
retrieved
16 July 2018
stated in
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
retrieved
16 July 2018
stated in
Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
cytoplasm
determination method or standard
IBA
IDA
IEA
TAS
7 references
retrieved
1 January 2018
stated in
NLRs join TLRs as innate sensors of pathogens
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IEA
retrieved
1 January 2018
stated in
Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
retrieved
1 January 2018
stated in
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
retrieved
1 January 2018
stated in
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IBA
biological process
positive regulation of NF-kappaB transcription factor activity
determination method or standard
IDA
TAS
IMP
6 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
TAS
retrieved
1 January 2018
stated in
A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IMP
retrieved
1 January 2018
stated in
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IMP
retrieved
1 January 2018
stated in
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
retrieved
1 January 2018
stated in
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
retrieved
1 January 2018
stated in
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
response to muramyl dipeptide
determination method or standard
IBA
IDA
IEA
IMP
5 references
retrieved
1 January 2018
stated in
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease
GOA
curator
UniProt
UniProt protein ID
Q9HC29
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IEA
retrieved
1 January 2018
stated in
Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
retrieved
1 January 2018
stated in
Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29
determination method or standard
IBA
Gene Atlas image
PBB GE NOD2 220066 at fs.png
732 × 530; 10 KB
0 references

Identifiers

MeSH descriptor ID
D053473
subject named as
Nod2 Signaling Adaptor Protein
0 references
Microsoft Academic ID
7573103
0 references
171044643
0 references
 
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