(Q41461407)

1 October 2017

The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling (English)

1 reference

Smoothened, frizzled class receptor

1 October 2017

1 reference

GOA release 2020-03-11

1

Pia Aanstad

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Didier Stainier

9

object named as

Didier Y R Stainier

1 reference

1 October 2017

7

Jan Huisken

1 reference

1 October 2017

Nicole Santos

2

1 reference

1 October 2017

Kevin C Corbit

3

1 reference

1 October 2017

Paul J Scherz

4

1 reference

1 October 2017

Le A Trinh

5

1 reference

1 October 2017

Willi Salvenmoser

6

1 reference

1 October 2017

Jeremy F Reiter

8

1 reference

1 October 2017

language of work or name

English

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publication date

21 May 2009

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1 October 2017

6

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based on heuristic

inferred from page(s)

published in

Current Biology

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1 October 2017

19

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1 October 2017

12

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1 October 2017

1034-1039

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Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Hedgehog regulates smoothened activity by inducing a conformational switch

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Role of the kinesin-2 family protein, KIF3, during mitosis

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Vertebrate Smoothened functions at the primary cilium

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Communicating with Hedgehogs

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Hedgehog signalling in the mouse requires intraflagellar transport proteins

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Small molecule modulation of Smoothened activity

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Patched acts catalytically to suppress the activity of Smoothened

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Sonic hedgehog induces the segregation of patched and smoothened in endosomes

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Sonic hedgehog signaling by the patched-smoothened receptor complex

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Guidance of primordial germ cell migration by the chemokine SDF-1.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892286

10.1016/J.CUB.2009.04.053

19 August 2018

Identifiers

DOI

1 reference

1 October 2017

1 reference

1 October 2017

PubMed publication ID

19464178

1 reference