(Q41083928)

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Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication

scientific article published on December 1, 1991

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26 September 2017

Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication (English)

1 reference

10.1002/J.1460-2075.1991.TB05011.X

https://api.crossref.org/works/10.1002/J.1460-2075.1991.TB05011.X

17 November 2022

immunoglobulin genes

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

DNA replication

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

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B. Rogerson

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

J. Hackett

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

A. Peters

3

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

D. Haasch

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

U. Storb

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

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1 December 1991

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26 September 2017

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1756738/?tool=EBI

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1756738/pdf/?tool=EBI

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

https://europepmc.org/articles/PMC453186

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Europe PubMed Central

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

https://europepmc.org/articles/PMC453186?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1756738

17 November 2022

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fj.1460-2075.1991.tb05011.x

1 reference

10.1002/J.1460-2075.1991.TB05011.X

https://api.crossref.org/works/10.1002/J.1460-2075.1991.TB05011.X

17 November 2022

http://onlinelibrary.wiley.com/wol1/doi/10.1002/j.1460-2075.1991.tb05011.x/fullpdf

1 reference

10.1002/J.1460-2075.1991.TB05011.X

https://api.crossref.org/works/10.1002/J.1460-2075.1991.TB05011.X

17 November 2022

The EMBO Journal

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

10

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

13

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

4331-4341

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Gene conversion: some implications for immunoglobulin genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Somatic diversification of immunoglobulins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Clusters of point mutations are found exclusively around rearranged antibody variable genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Antibody diversity: somatic hypermutation of rearranged VH genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Patterns of somatic mutations in immunoglobulin variable genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Gene conversion and the generation of antibody diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Initiation of eukaryotic DNA replication in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Animal virus DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Hypothesis: somatic hypermutation by gene conversion via the error prone DNA----RNA----DNA information loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Analysis of somatic mutations in kappa transgenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Evidence that replication initiates at only some of the potential origins in each oligomeric form of bovine papillomavirus type 1 DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Heavy-chain class switch does not terminate somatic mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

The mouse immunoglobulin kappa light-chain genes are located in early- and late-replicating regions of chromosome 6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Somatic mutation in constant regions of mouse lambda 1 light chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Exonucleolytic proofreading of leading and lagging strand DNA replication errors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Origins of replication: timing and chromosomal position

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Initiation of simian virus 40 DNA synthesis in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

A method for the recovery of DNA from agarose gels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Eukaryotic chromosome replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

26 September 2017

Somatic mutation of immunoglobulin light-chain variable-region genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

A linkage map of the mouse immunoglobulin lambda light chain locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

Distribution of mutations around rearranged heavy-chain antibody variable-region genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

Molecular characterization of single memory B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

Somatic hypermutation of the JC intron is markedly reduced in unrearranged kappa and H alleles and is unevenly distributed in rearranged alleles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

17 June 2018

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

19 August 2018

Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

19 August 2018

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453186

19 August 2018

Origin of Antibody Variation

1 reference

https://pubmed.ncbi.nlm.nih.gov/1756738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Position of the rearranged V kappa and its 5' flanking sequences determines the location of somatic mutations in the J kappa locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/1756738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment

1 reference

https://pubmed.ncbi.nlm.nih.gov/1756738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Templated insertions in the rearranged chicken IgL V gene segment arise by intrachromosomal gene conversion

1 reference

https://pubmed.ncbi.nlm.nih.gov/1756738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

V gene rearrangement is required to fully activate the hypermutation mechanism in B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1756738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/1756738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in gene position are accompanied by a change in time of replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/1756738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/J.1460-2075.1991.TB05011.X

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1756738

17 November 2022

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

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