(Q40976813)

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Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response

scientific article published on January 1999

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Europe PubMed Central

PubMed publication ID

25 September 2017

Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

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Europe PubMed Central

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25 September 2017

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Europe PubMed Central

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25 September 2017

author name string

Korpelainen EI

1

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Europe PubMed Central

PubMed publication ID

25 September 2017

Kärkkäinen M

2

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Europe PubMed Central

PubMed publication ID

25 September 2017

Gunji Y

3

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Europe PubMed Central

PubMed publication ID

25 September 2017

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publication date

1 January 1999

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Europe PubMed Central

PubMed publication ID

25 September 2017

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Europe PubMed Central

PubMed publication ID

25 September 2017

18

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Europe PubMed Central

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25 September 2017

1

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Europe PubMed Central

PubMed publication ID

25 September 2017

1-8

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Europe PubMed Central

PubMed publication ID

25 September 2017

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

1 reference

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Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1 reference

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

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Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

1 reference

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STATs and Gene Regulation

1 reference

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Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

1 reference

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The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

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Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

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Bmx Tyrosine Kinase Is Specifically Expressed in the Endocardium and the Endothelium of Large Arteries

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The biology of vascular endothelial growth factor

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

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Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

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Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

1 reference

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Signaling Vascular Morphogenesis and Maintenance

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STATs: signal transducers and activators of transcription

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Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria

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Hyperplasia of lymphatic vessels in VEGF-C transgenic mice

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A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

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Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

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p53: puzzle and paradigm

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Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor

1 reference

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Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4

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Stat5a is mandatory for adult mammary gland development and lactogenesis.

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

1 reference

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Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5

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Comparative study on the phosphotyrosine motifs of different cytokine receptors involved in STAT5 activation

1 reference

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High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1 reference

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Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family

1 reference

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A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

1 reference

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Stat6 and Jak1 are common elements in platelet-derived growth factor and interleukin-4 signal transduction pathways in NIH 3T3 fibroblasts

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Expression of a novel form of p21Cip1/Waf1 in UV-irradiated and transformed cells

1 reference

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The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202288

7 January 2021

based on heuristic

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p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1 reference

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Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

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The Phosphorylated 1169-Tyrosine Containing Region of Flt-1 Kinase (VEGFR-1) Is a Major Binding Site for PLCγ

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation

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Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

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Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

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The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts

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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

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Novel form of p21(WAF1/CIP1/SDI1) protein in phorbol ester-induced G2/M arrest

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Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1 reference

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Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1 reference

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based on heuristic

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Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF β-receptor juxtamembrane and kinase insert domains

1 reference

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based on heuristic

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Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins

1 reference

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based on heuristic

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Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2

1 reference

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based on heuristic

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Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

1 reference

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Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

1 reference

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Identifiers

10.1038/SJ.ONC.1202288

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

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