(Q40887247)

24 September 2017

title

Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras (English)

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24 September 2017

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Tremain R

1

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24 September 2017

Marko M

2

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24 September 2017

Kinnimulki V

3

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24 September 2017

Ueno H

4

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24 September 2017

Bottinger E

5

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24 September 2017

Glick A

6

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24 September 2017

language of work or name

English

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publication date

1 March 2000

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24 September 2017

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24 September 2017

volume

19

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24 September 2017

issue

13

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24 September 2017

page(s)

1698-1709

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

24 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Expression of a dominant negative type II TGF-beta receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

21 January 2018

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Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

21 January 2018

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p14ARF links the tumour suppressors RB and p53.

21 January 2018

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The ras gene family and human carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

21 January 2018

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Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.

21 January 2018

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v-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis.

21 January 2018

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TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

21 January 2018

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Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

21 January 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

CDC25 phosphatases as potential human oncogenes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

21 January 2018

1 reference

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Cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

21 January 2018

1 reference

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Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

21 January 2018

1 reference

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Genetic integrity of transforming growth factor beta (TGF-beta) receptors in cervical carcinoma cell lines: loss of growth sensitivity but conserved transcriptional response to TGF-beta

21 January 2018

1 reference

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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

D-type cyclin-dependent kinase activity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Parasexual approaches to the genetics of man

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

TGF beta signals through a heteromeric protein kinase receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Adenovirus-mediated transfer of a truncated transforming growth factor-beta (TGF-beta) type II receptor completely and specifically abolishes diverse signaling by TGF-beta in vascular wall cells in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Human Smad3 and Smad4 are sequence-specific transcription activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

[1] Isolation and utilization of epidermal keratinocytes for oncogene research

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

7 January 2021

Gene expression in quiescent and senescent fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

7 January 2021

Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

7 January 2021

cHa-ras proto-oncogene. Amplification and overexpression in UV-B-induced mouse skin papillomas and carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

7 January 2021

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

7 January 2021

Mechanism of enhancement of DNA expression consequent to cointernalization of a replication-deficient adenovirus and unmodified plasmid DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

7 January 2021

Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203471

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203471

1 reference

Dimensions Publication ID

24 September 2017

1006174809

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1 reference