(Q40780586)

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Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells

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Europe PubMed Central

PubMed publication ID

23 September 2017

Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells (English)

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Europe PubMed Central

PubMed publication ID

23 September 2017

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apoptotic process

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author name string

Yu Q

1

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Europe PubMed Central

PubMed publication ID

23 September 2017

Rose JH

2

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23 September 2017

Zhang H

3

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23 September 2017

Pommier Y

4

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23 September 2017

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publication date

1 September 2001

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23 September 2017

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23 September 2017

505

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23 September 2017

1

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Europe PubMed Central

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23 September 2017

7-12

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Europe PubMed Central

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23 September 2017

Cell cycle checkpoints: preventing an identity crisis

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Cancer. p53, guardian of the genome

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A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage

1 reference

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

1 reference

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

1 reference

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

1 reference

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

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A kinase from fission yeast responsible for blocking mitosis in S phase

1 reference

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Meiotic DNA replication checkpoint control in fission yeast

1 reference

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Replication checkpoint enforced by kinases Cds1 and Chk1.

1 reference

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Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

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The G(2) checkpoint is maintained by redundant pathways

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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Caspases: enemies within

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The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression.

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Adenovirus E1A proteins inhibit activation of transcription by p53.

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Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins

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21 January 2018

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

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21 January 2018

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

1 reference

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Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

1 reference

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21 January 2018

DNA damage and checkpoint pathways: molecular anatomy and interactions with repair

1 reference

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7 January 2021

Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells

1 reference

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7 January 2021

Identifiers

10.1016/S0014-5793(01)02756-9

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Europe PubMed Central

PubMed publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

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