(Q40660071)

22 September 2017

title

Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies (English)

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22 September 2017

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Atsushi Nagai

2

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author name string

Jae K Ryu

1

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22 September 2017

Jean Kim

3

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22 September 2017

Min C Lee

4

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22 September 2017

James G McLarnon

5

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22 September 2017

Seung U Kim

6

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22 September 2017

publication date

1 March 2003

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22 September 2017

published in

Neurobiology of Disease

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22 September 2017

volume

12

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22 September 2017

issue

2

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22 September 2017

page(s)

121-132

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Inflammation and Alzheimer's disease

22 September 2017

cites work

1 reference

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7 January 2021

3-Nitropropionate, the toxic substance of Indigofera , is a suicide inactivator of succinate dehydrogenase

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Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

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Aging, energy, and oxidative stress in neurodegenerative diseases.

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Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

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7 January 2021

3-Nitropropionic acid animal model and Huntington's disease

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7 January 2021

3-Nitropropionic acid increases the intracellular Ca2+ in cultured astrocytes by reverse operation of the Na+-Ca2+ exchanger

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7 January 2021

Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington's disease

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7 January 2021

Astrocytes are more vulnerable than neurons to cellular Ca2+ overload induced by a mitochondrial toxin, 3-nitropropionic acid

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Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.

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Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid

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7 January 2021

Delayed dystonia with striatal CT lucencies induced by a mycotoxin (3-nitropropionic acid)

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7 January 2021

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Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

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7 January 2021

Analysis of mitochondrial free radical generation in animal models of neuronal disease

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7 January 2021

Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid

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7 January 2021

Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release

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7 January 2021

Dual role of inflammatory stimuli in activation-induced cell death of mouse microglial cells. Initiation of two separate apoptotic pathways via induction of interferon regulatory factor-1 and caspase-11.

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NO as an autocrine mediator in the apoptosis of activated microglial cells: correlation between activation and apoptosis of microglial cells

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Molecular consequences of activated microglia in the brain: overactivation induces apoptosis.

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White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat.

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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

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7 January 2021

Effects of ATP and elevated K+ on K+ currents and intracellular Ca2+ in human microglia

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7 January 2021

Generation and characterization of immortalized human microglial cell lines: expression of cytokines and chemokines

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7 January 2021

Acute 3-nitropropionic acid intoxication induces striatal astrocytic cell death and dysfunction of the blood-brain barrier: involvement of dopamine toxicity

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7 January 2021

Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis

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7 January 2021

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

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7 January 2021

Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease.

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7 January 2021

Early and progressive accumulation of reactive microglia in the Huntington disease brain

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7 January 2021

Decreased expression of bcl-2 and bcl-x mRNA coincides with apoptosis following intracerebral administration of 3-nitropropionic acid

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7 January 2021

Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity

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7 January 2021

Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

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7 January 2021

Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease

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7 January 2021

DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

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7 January 2021

Activation of purinergic P2X receptors inhibits P2Y-mediated Ca2+ influx in human microglia

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7 January 2021

10.1016/S0969-9961(03)00002-0

Identifiers

DOI

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22 September 2017

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