(Q40022130)

18211286

16 September 2017

title

Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells (English)

1 reference

16 September 2017

0 references

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3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

Ramon Colomer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

Javier A Menendez

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

author name string

A Vazquez-Martin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

R Lupu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

publication date

1 February 2008

1 reference

16 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

volume

41

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

page(s)

59-85

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

14 May 2020

cites work

1 reference

Crossref

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Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development

21 January 2018

1 reference

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https://api.crossref.org/works/10.1111%2FJ.1365-2184.2007.00498.X

Signal transduction and oncogenesis by ErbB/HER receptors

21 January 2018

1 reference

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https://api.crossref.org/works/10.1111%2FJ.1365-2184.2007.00498.X

Energy boost: the Warburg effect returns in a new theory of cancer

21 January 2018

1 reference

12 December 2020

Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer

1 reference

12 December 2020

The isopeptidase USP2a protects human prostate cancer from apoptosis

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12 December 2020

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12 December 2020

Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.

1 reference

12 December 2020

FGF2 as an autocrine growth factor for immortal human breast epithelial cells.

1 reference

12 December 2020

Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.

1 reference

12 December 2020

Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells

1 reference

12 December 2020

Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells

1 reference

12 December 2020

SREBP transcription factors: master regulators of lipid homeostasis

1 reference

12 December 2020

Targeting the HER-kinase axis in cancer

1 reference

12 December 2020

Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

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12 December 2020

Small molecules with EGFR-TK inhibitor activity

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12 December 2020

ERBB receptors and cancer: the complexity of targeted inhibitors

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12 December 2020

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

1 reference

12 December 2020

Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer

1 reference

12 December 2020

Invasive phenotype of MCF10A cells overexpressing c-Ha-ras and c-erbB-2 oncogenes.

1 reference

12 December 2020

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

1 reference

12 December 2020

Energy deregulation: licensing tumors to grow

1 reference

12 December 2020

Why do cancers have high aerobic glycolysis?

1 reference

12 December 2020

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

1 reference

12 December 2020

Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment

1 reference

12 December 2020

A cell line (HBL-100) established from human breast milk

1 reference

12 December 2020

Untangling the ErbB signalling network

1 reference

12 December 2020

Glucose metabolism and cancer

1 reference

12 December 2020

Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor

1 reference

12 December 2020

Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro

1 reference

12 December 2020

Tumor cell metabolism: the marriage of molecular genetics and proteomics with cellular intermediary metabolism; proceed with caution!

1 reference

12 December 2020

9 Fatty acid synthase from rabbit mammary gland

1 reference

12 December 2020

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

1 reference

12 December 2020

Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells.

1 reference

12 December 2020

Obesity, fatty acid synthase, and cancer: serendipity or forgotten causal linkage?

1 reference

12 December 2020

EGF-ERBB signalling: towards the systems level

1 reference

12 December 2020

Tumor metabolism: new opportunities for cancer therapy

1 reference

12 December 2020

Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?

1 reference

12 December 2020

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines

1 reference

12 December 2020

Increased lipogenesis in steroid-responsive cancer cells: mechanisms of regulation, role in cancer cell biology and perspectives on clinical applications.

1 reference

12 December 2020

Cancer's molecular sweet tooth and the Warburg effect.

1 reference

12 December 2020

Architecture of mammalian fatty acid synthase at 4.5 A resolution

1 reference

12 December 2020

Epithelial HBL-100 cell line derived from milk of an apparently healthy woman harbours SV40 genetic information

1 reference

12 December 2020

Fatty acid synthase and cancer: new application of an old pathway

1 reference

12 December 2020

MCF10AT: a model for the evolution of cancer from proliferative breast disease

1 reference

12 December 2020

Fatty acid synthase: a metabolic oncogene in prostate cancer?

1 reference

12 December 2020

Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-li

1 reference

12 December 2020

Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?

1 reference

12 December 2020

Increased lipogenesis in cancer cells: new players, novel targets.

1 reference

12 December 2020

Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells.

1 reference

12 December 2020

In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells

1 reference

12 December 2020

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1 reference

12 December 2020

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts

1 reference

12 December 2020

Lapatinib: a novel EGFR/HER2 tyrosine kinase inhibitor for cancer.

1 reference

12 December 2020

Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related

1 reference

12 December 2020

Xenograft model of progressive human proliferative breast disease

1 reference

12 December 2020

Update on HER-2 as a target for cancer therapy: intracellular signaling pathways of ErbB2/HER-2 and family members

1 reference

12 December 2020

Development of an autocrine neuregulin signaling loop with malignant transformation of human breast epithelial cells

1 reference

12 December 2020

Synthesis and antitumor activity of an inhibitor of fatty acid synthase

1 reference

12 December 2020

ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.

1 reference

12 December 2020

Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity

1 reference

12 December 2020

Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells.

1 reference

12 December 2020

Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase

1 reference

12 December 2020

Acquisition of tumorigenic potential in the human myoepithelial HBL100 cell line is associated with decreased expression of HLA class I, class II and integrin β3 and increased expression ofc-myc

1 reference

12 December 2020

Fatty acid synthase, a proficient multifunctional enzyme

1 reference

12 December 2020

Fatty acid synthesis: a potential selective target for antineoplastic therapy

1 reference

12 December 2020

Additive effects of c-erbB-2, c-Ha-ras, and transforming growth factor-alpha genes on in vitro transformation of human mammary epithelial cells

1 reference

12 December 2020

Karyotype evolution of the human HBL-100 cell line and mapping of the integration site of SV40 DNA.

1 reference

12 December 2020

The animal fatty acid synthase: one gene, one polypeptide, seven enzymes

1 reference

12 December 2020

On the Origin of Cancer Cells

1 reference

12 December 2020

Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?

1 reference

12 December 2020

10.1111/J.1365-2184.2007.00498.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496011&resulttype=core&format=json

14 May 2020

18211286

1 reference