(Q39978729)

16 September 2017

title

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity (English)

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16 September 2017

author name string

Lucía Chávez-Gutiérrez

1

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16 September 2017

Alexandra Tolia

2

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16 September 2017

Elke Maes

3

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16 September 2017

Tong Li

4

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16 September 2017

Philip C Wong

5

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16 September 2017

Bart de Strooper

6

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16 September 2017

language of work or name

English

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publication date

23 May 2008

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Journal of Biological Chemistry

16 September 2017

published in

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16 September 2017

volume

283

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16 September 2017

issue

29

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16 September 2017

page(s)

20096-20105

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Gamma-secretase: proteasome of the membrane?

16 September 2017

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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Nicastrin functions as a gamma-secretase-substrate receptor

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Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

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Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Nicastrin binds to membrane-tethered Notch

21 January 2018

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Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

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Crystal structure of the ectodomain of human transferrin receptor

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M803040200

1 reference

16 September 2017

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