(Q39770880)

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Anticancer therapeutics that target selenoenzymes: synthesis, characterization, in vitro cytotoxicity, and thioredoxin reductase inhibition of a series of gold(I) complexes containing hydrophilic phosphine ligands

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Europe PubMed Central

PubMed publication ID

14 September 2017

Anticancer therapeutics that target selenoenzymes: synthesis, characterization, in vitro cytotoxicity, and thioredoxin reductase inhibition of a series of gold(I) complexes containing hydrophilic phosphine ligands (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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14 September 2017

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Paul J Dyson

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Maria Pia Rigobello

6

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Maria Pia Rigobello

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Europe PubMed Central

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14 September 2017

Alberto Bindoli

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Alberto Bindoli

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14 September 2017

Francesca Sorrentino

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Francesca Sorrentino

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14 September 2017

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Elena Vergara

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14 September 2017

Olivier Zava

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14 September 2017

Elena Cerrada

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14 September 2017

Mariano Laguna

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14 September 2017

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1 January 2010

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14 September 2017

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Europe PubMed Central

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14 September 2017

5

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14 September 2017

1

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14 September 2017

96-102

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Europe PubMed Central

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14 September 2017

A hypothesis on the catalytic mechanism of the selenoenzyme thioredoxin reductase

1 reference

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New clues for platinum antitumor chemistry: kinetically controlled metal binding to DNA.

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Chemistry. Metal-based therapeutics

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Ruthenium antimetastatic agents

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Metal-based antitumour drugs in the post genomic era.

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Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action

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Anti-cancer potential of gold complexes

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Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligands

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Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.

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Gold derivatives for the treatment of cancer

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Gold-based therapeutic agents

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New trends for metal complexes with anticancer activity

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Physiological functions of thioredoxin and thioredoxin reductase

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Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

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Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

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Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases

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A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: implications for anticancer therapeutics targeted to mitochondria.

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Synthesis, characterization, and in vitro cytotoxicity of some gold(I) and trans platinum(II) thionate complexes containing water-soluble PTA and DAPTA ligands. X-ray crystal structures of [Au(SC4H3N2)(PTA)], trans-[Pt(SC4H3N2)2(PTA)2], trans-[Pt(SC

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Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds

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[Ru(η6-p-cymene)Cl2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

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Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy

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Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta

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Synthesis, catalytic properties and biological activity of new water soluble ruthenium cyclopentadienyl PTA complexes [(C5R5)RuCl(PTA)2] (R = H, Me; PTA = 1,3,5-triaza-7-phosphaadamantane).

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In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case for Organometallic Anticancer Drugs Not Based on Ruthenium

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Classical and Non-Classical Ruthenium-Based Anticancer Drugs: Towards Targeted Chemotherapy

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7 January 2021

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In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake.

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Chemical behavior and in vitro activity of mixed phosphine gold(I) compounds on melanoma cell lines

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Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.

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Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

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7 January 2021

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Metallothioneins and platinum(II) anti-tumor compounds

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Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines

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Activity of Rat Cytosolic Thioredoxin Reductase Is Strongly Decreased bytrans-[Bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: First Report of Relevant Thioredoxin Reductase Inhibition for a Ruthenium Compound

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Differential effect of calcium ions on the cytosolic and mitochondrial thioredoxin reductase

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Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases

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Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

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A mass spectrometric investigation of the binding of gold antiarthritic agents and the metabolite [Au(CN)2]− to human serum albumin

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Kinetics and Mechanism of the Reaction between Serum Albumin and Auranofin (and Its Isopropyl Analogue) in Vitro

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The thioredoxin system—From science to clinic

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Thioredoxin reductase

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The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis

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Ethylene glycol and amino acid derivatives of 5-aminolevulinic acid as new photosensitizing precursors of protoporphyrin IX in cells

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Rat liver thioredoxin and thioredoxin reductase: purification and characterization

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Purification of Mitochondrial Thioredoxin Reductase and Its Involvement in the Redox Regulation of Membrane Permeability

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10.1002/CMDC.200900370

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Europe PubMed Central

PubMed publication ID

14 September 2017

release_pn6ihuvorngovma7vin3b2t4vq

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https://api.fatcat.wiki/v0/release/pn6ihuvorngovma7vin3b2t4vq

24 November 2022

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mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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