(Q39712547)

14 September 2017

5 references

12 October 2019

20 November 2019

26 August 2020

24 December 2020

17 February 2023

Smad4 (DPC4)--a potent tumour suppressor? (English)

1 reference

14 September 2017

1 reference

12 October 2019

1 reference

20 November 2019

1 reference

26 August 2020

tumor suppressor gene

1 reference

24 December 2020

Duff EK

1

1 reference

14 September 2017

Clarke AR

series ordinal

2

1 reference

14 September 2017

language of work or name

English

0 references

publication date

1 December 1998

6 references

British Journal of Cancer

14 September 2017

12 October 2019

20 November 2019

26 August 2020

24 December 2020

17 February 2023

6 references

14 September 2017

12 October 2019

20 November 2019

26 August 2020

24 December 2020

17 February 2023

78

1 reference

14 September 2017

12

1 reference

14 September 2017

1615-1619

1 reference

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

TGF-β signalling from cell membrane to nucleus through SMAD proteins

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Inactivation of Smad4 in gastric carcinomas

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Smad4 and FAST-1 in the assembly of activin-responsive factor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

A structural basis for mutational inactivation of the tumour suppressor Smad4

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Tumor-suppressive pathways in pancreatic carcinoma.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

A transcriptional partner for MAD proteins in TGF-beta signalling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Mad-related genes in the human

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Mutation and cancer: statistical study of retinoblastoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

TGF beta signals through a heteromeric protein kinase receptor complex

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Induction of Apoptosis by DPC4, a Transcriptional Factor Regulated by Transforming Growth Factor-β through Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) Signaling Pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

A human Mad protein acting as a BMP-regulated transcriptional activator

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Analysis of the Smad2 gene in hematological malignancies.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Frequency of Smad gene mutations in human cancers.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

DPC4 gene mutation in colitis associated neoplasia

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Nomenclature: vertebrate mediators of TGFbeta family signals

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Requirement for a functional Rb-1 gene in murine development

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

The type II TGF-beta receptor signals diverse responses in cooperation with the type I receptor

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063251

Alterations of the tumour suppressor gene DCC in neuroblastoma

20 August 2018

1 reference

12 December 2020

Evidence for a positive role of transforming growth factor-beta in human breast cancer cell tumorigenesis

1 reference

12 December 2020

A subset of p53-deficient embryos exhibit exencephaly

1 reference

12 December 2020

Homozygous deletion map at 18q21.1 in pancreatic cancer

1 reference

12 December 2020

DPC4 gene in various tumor types

1 reference

12 December 2020

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1 reference

12 December 2020

Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma

1 reference

12 December 2020

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1 reference

12 December 2020

Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms

1 reference

12 December 2020

Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers

1 reference

12 December 2020

Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.1998.731

1 reference

14 September 2017

1 reference

14 September 2017

PubMed publication ID

9862572

1 reference