(Q39337480)

11 September 2017

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title

TET-mediated active DNA demethylation: mechanism, function and beyond (English)

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11 September 2017

Xiaoji Wu

1

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11 September 2017

Yi Zhang

series ordinal

2

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11 September 2017

publication date

30 May 2017

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11 September 2017

published in

Nature Reviews Genetics

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11 September 2017

volume

18

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11 September 2017

issue

9

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11 September 2017

page(s)

517-534

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DNA methylation: roles in mammalian development

11 September 2017

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Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation

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TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine

31 March 2020

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Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

31 March 2020

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Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development

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Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules

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Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration

31 March 2020

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Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA

31 March 2020

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Structural insight into substrate preference for TET-mediated oxidation

31 March 2020

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Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.

31 March 2020

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Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism.

31 March 2020

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Distributive Processing by the Iron(II)/α-Ketoglutarate-Dependent Catalytic Domains of the TET Enzymes Is Consistent with Epigenetic Roles for Oxidized 5-Methylcytosine Bases

31 March 2020

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Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing

31 March 2020

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Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.

31 March 2020

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A sensitive approach to map genome-wide 5-hydroxymethylcytosine and 5-formylcytosine at single-base resolution.

31 March 2020

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TET enzymes, TDG and the dynamics of DNA demethylation.

31 March 2020

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Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

31 March 2020

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Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

31 March 2020

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Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability

31 March 2020

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Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA

31 March 2020

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Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA.

31 March 2020

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Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.

31 March 2020

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Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress.

31 March 2020

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TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation

31 March 2020

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Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

31 March 2020

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Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells

31 March 2020

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Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain

31 March 2020

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Effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation

31 March 2020

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TET family proteins: oxidation activity, interacting molecules, and functions in diseases

31 March 2020

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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

31 March 2020

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine

31 March 2020

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Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals

31 March 2020

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MicroRNA-15b promotes neurogenesis and inhibits neural progenitor proliferation by directly repressing TET3 during early neocortical development

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

miR-29 represses the activities of DNA methyltransferases and DNA demethylases

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

MicroRNA-494 is a master epigenetic regulator of multiple invasion-suppressor microRNAs by targeting ten eleven translocation 1 in invasive human hepatocellular carcinoma tumors

31 March 2020

1 reference

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Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

DAZL regulates Tet1 translation in murine embryonic stem cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

Regulation of TET protein stability by calpains.

31 March 2020

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Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.

31 March 2020

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Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2017.33

WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

PPARγ-induced PARylation promotes local DNA demethylation by production of 5-hydroxymethylcytosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

The discovery of 5-formylcytosine in embryonic stem cell DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5-Formylcytosine can be a stable DNA modification in mammals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5-Hydroxymethylcytosine is a predominantly stable DNA modification.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

DNA-binding factors shape the mouse methylome at distal regulatory regions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Global epigenomic reconfiguration during mammalian brain development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genomic mapping of 5-hydroxymethylcytosine in the human brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Role of Tet proteins in enhancer activity and telomere elongation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Cooperative Action between SALL4A and TET Proteins in Stepwise Oxidation of 5-Methylcytosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5-Formylcytosine alters the structure of the DNA double helix

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Reprogramming the methylome: erasing memory and creating diversity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Transcriptional activation of transposable elements in mouse zygotes is independent of Tet3-mediated 5-methylcytosine oxidation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Chromosome methylation patterns during mammalian preimplantation development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Programming and inheritance of parental DNA methylomes in mammals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

PGC7/Stella protects against DNA demethylation in early embryogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

PGC7 suppresses TET3 for protecting DNA methylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Deterministic and stochastic allele specific gene expression in single mouse blastomeres

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Simultaneous mapping of active DNA demethylation and sister chromatid exchange in single cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

De novo DNA methylation drives 5hmC accumulation in mouse zygotes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Haploinsufficiency, but not defective paternal 5mC oxidation, accounts for the developmental defects of maternal Tet3 knockouts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Epigenetic events in mammalian germ-cell development: reprogramming and beyond

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

DNA Demethylation Dynamics in the Human Prenatal Germline

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Specification and epigenetic programming of the human germ line

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

A unique regulatory phase of DNA methylation in the early mammalian embryo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet1 controls meiosis by regulating meiotic gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Role of Tet1 in erasure of genomic imprinting

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Global profiling of DNA methylation erasure in mouse primordial germ cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Epigenetic reprogramming in mouse primordial germ cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Loss of Tet enzymes compromises proper differentiation of embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Control of Foxp3 stability through modulation of TET activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Neuronal activity modifies the DNA methylation landscape in the adult brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Covalent modification of DNA regulates memory formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet1 regulates adult hippocampal neurogenesis and cognition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet1 is critical for neuronal activity-regulated gene expression and memory extinction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Experience-dependent DNA methylation regulates plasticity in the developing visual cortex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Mutation in TET2 in myeloid cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Acquired mutations in TET2 are common in myelodysplastic syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Role of TET enzymes in DNA methylation, development, and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET1 is a tumor suppressor of hematopoietic malignancy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Charting oxidized methylcytosines at base resolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Mechanism and function of oxidative reversal of DNA and RNA methylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Base-Resolution Analysis of 5-Hydroxymethylcytosine by One-Pot Bisulfite-Free Chemical Conversion with Peroxotungstate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tissue-specific Distribution and Dynamic Changes of 5-Hydroxymethylcytosine in Mammalian Genomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Single-CpG resolution mapping of 5-hydroxymethylcytosine by chemical labeling and exonuclease digestion identifies evolutionarily unconserved CpGs as TET targets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET2 promotes histone O-GlcNAcylation during gene transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Acute loss of TET function results in aggressive myeloid cancer in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2017.33

LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).

31 March 2020

1 reference

12 December 2020

RRHP: a tag-based approach for 5-hydroxymethylcytosine mapping at single-site resolution

1 reference

12 December 2020

DNA modification mechanisms and gene activity during development

1 reference

12 December 2020

Mitochondria and the death of oocytes

1 reference

12 December 2020

Active DNA demethylation: many roads lead to Rome.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRG.2017.33

1 reference

11 September 2017

1 reference