(Q39187790)

English

Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.

scientific article published on 13 March 2013

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24 February 2020

Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells (English)

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24 February 2020

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24 February 2020

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24 February 2020

Craig W. Lindsley

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Craig W Lindsley

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24 February 2020

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Matthew C O'Reilly

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24 February 2020

Sarah A Scott

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24 February 2020

Kyle A Brown

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24 February 2020

J Scott Daniels

6

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24 February 2020

Ryan Morrison

7

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24 February 2020

H Alex Brown

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24 February 2020

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13 March 2013

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24 February 2020

Journal of Medicinal Chemistry

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24 February 2020

56

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24 February 2020

6

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24 February 2020

2695-2699

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24 February 2020

Phospholipase D: enzymology, functionality, and chemical modulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

10 September 2017

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

10 September 2017

Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

10 September 2017

Design, Synthesis, and Biological Evaluation of Halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 Inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

10 September 2017

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

10 September 2017

Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

10 September 2017

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

10 September 2017

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

10 September 2017

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

15 June 2018

Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

21 August 2018

Biochemical analysis of phospholipase D.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

21 August 2018

Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

21 August 2018

The clinical significance of halopemide, a dopamine-blocker related to the butyrophenones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3632306

21 August 2018

Overexpression of phospholipase D1 in human breast cancer tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/23445448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of halopemide for phospholipase D2 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23445448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased activity and intranuclear expression of phospholipase D2 in human renal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23445448

12 December 2020

based on heuristic

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Identifiers

10.1021/JM301782E

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24 February 2020

PMC publication ID

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24 February 2020

PubMed publication ID

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24 February 2020

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