(Q38620104)

English

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils

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Europe PubMed Central

PMC publication ID

4 September 2017

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils (English)

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

0 references

reactive oxygen species

1 reference

based on heuristic

inferred from title

8

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Europe PubMed Central

PMC publication ID

4 September 2017

object named as

Jay H Bream

6

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author name string

Rajesh K Thimmulappa

1

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Ralph J Fuchs

2

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Deepti Malhotra

3

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Catherine Scollick

4

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Kassim Traore

5

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Michael A Trush

7

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Michael B Sporn

9

1 reference

Europe PubMed Central

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4 September 2017

Thomas W Kensler

10

1 reference

Europe PubMed Central

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4 September 2017

Shyam Biswal

11

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Europe PubMed Central

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4 September 2017

publication date

1 November 2007

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Europe PubMed Central

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4 September 2017

Antioxidants & Redox Signaling

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

9

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

11

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

1963-1970

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

1 reference

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6 September 2017

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

1 reference

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6 September 2017

Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

1 reference

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6 September 2017

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.

1 reference

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6 September 2017

Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages

1 reference

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6 September 2017

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

New insights into cellular mechanisms during sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

1 reference

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6 September 2017

The role of oxidative stress in adult critical care

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

The pathophysiology and treatment of sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

6 September 2017

Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

14 September 2017

The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

14 September 2017

A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

14 September 2017

Role of neutrophils in experimental septicemia and septic arthritis induced by Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

14 September 2017

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

23 June 2018

Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

Participation of superoxide in neutrophil activation and cytokine production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

The transcription factor NRF2 protects against pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

Nuclear factor-kappaB and its role in sepsis-associated organ failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

Role of NRF2 in protection against hyperoxic lung injury in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396226

31 August 2018

The Role of Neutrophils in Producing Hepatocellular Dysfunction during the Hyperdynamic Stage of Sepsis in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17822364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Harmful and protective roles of neutrophils in sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17822364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphonuclear leukocyte dysfunction syndrome in patients with increasing sepsis severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17822364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1089/ARS.2007.1745

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

ResearchGate publication ID

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