(Q38281336)

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Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells

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scholarly article

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Europe PubMed Central

PMC publication ID

1 September 2017

Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells (English)

1 reference

Europe PubMed Central

PMC publication ID

1 September 2017

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colon carcinoma

1 reference

based on heuristic

inferred from title

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inferred from title

author name string

Tapati Mazumdar

1

1 reference

Europe PubMed Central

PMC publication ID

1 September 2017

Jennifer Devecchio

2

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Europe PubMed Central

PMC publication ID

1 September 2017

Akwasi Agyeman

3

1 reference

Europe PubMed Central

PMC publication ID

1 September 2017

Ting Shi

4

1 reference

Europe PubMed Central

PMC publication ID

1 September 2017

Janet A Houghton

5

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Europe PubMed Central

PMC publication ID

1 September 2017

language of work or name

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publication date

11 July 2011

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Europe PubMed Central

PMC publication ID

1 September 2017

number of pages

11

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Cancer Research

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Europe PubMed Central

PMC publication ID

1 September 2017

71

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Europe PubMed Central

PMC publication ID

1 September 2017

17

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Europe PubMed Central

PMC publication ID

1 September 2017

5904-5914

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Europe PubMed Central

PMC publication ID

1 September 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3165104/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165104

6 September 2017

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

1 reference

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The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth

1 reference

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Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation

1 reference

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Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation

1 reference

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Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway

1 reference

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Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency

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1 reference

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E2F4 function in G2: maintaining G2-arrest to prevent mitotic entry with damaged DNA.

1 reference

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

1 reference

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Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas

1 reference

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

1 reference

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Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

1 reference

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DNA damage checkpoints and cancer

1 reference

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DNA damage checkpoint, damage repair, and genome stability

1 reference

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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

1 reference

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The Hedgehog response network: sensors, switches, and routers

1 reference

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G1 and S-phase checkpoints, chromosome instability, and cancer

1 reference

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GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter

1 reference

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Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment

1 reference

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Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

1 reference

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Checking on the fork: the DNA-replication stress-response pathway

1 reference

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

1 reference

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Cyclin A in cell cycle control and cancer

1 reference

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Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

1 reference

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Hedgehog signaling in animal development: paradigms and principles

1 reference

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Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

1 reference

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Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

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DNA double-strand breaks: signaling, repair and the cancer connection

1 reference

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The DNA damage response: putting checkpoints in perspective

1 reference

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1 reference

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Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

1 reference

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Gli proteins encode context-dependent positive and negative functions: implications for development and disease

1 reference

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1 reference

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WAF1 Retards S-Phase Progression Primarily by Inhibition of Cyclin-Dependent Kinases

1 reference

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

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Inhibition of cyclin-dependent kinases by p21

1 reference

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Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells

1 reference

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1 reference

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1 reference

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1 reference

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31 August 2018

Sonic hedgehog relates to colorectal carcinogenesis.

1 reference

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Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.

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Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability

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Bivariate analysis of DNA content and expression of cyclin proteins

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Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

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31 August 2018

Identifiers

10.1158/0008-5472.CAN-10-4173

1 reference

Europe PubMed Central

PMC publication ID

1 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 September 2017

ResearchGate publication ID

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