(Q38132668)

29 August 2017

title

Molecular control of the NEMO family of ubiquitin-binding proteins (English)

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29 August 2017

Kristopher Clark

1

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29 August 2017

Sambit Nanda

series ordinal

2

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29 August 2017

Philip Cohen

series ordinal

3

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29 August 2017

publication date

29 August 2013

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Nature Reviews Molecular Cell Biology

29 August 2017

published in

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29 August 2017

volume

14

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29 August 2017

issue

10

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29 August 2017

page(s)

673-685

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

29 August 2017

cites work

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

21 January 2018

1 reference

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

21 January 2018

1 reference

IKK Regulation and Human Genetics

21 January 2018

1 reference

DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out.

21 January 2018

1 reference

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

21 January 2018

1 reference

Structural Basis for Recognition of Diubiquitins by NEMO

21 January 2018

1 reference

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

1 reference

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

1 reference

Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1

21 January 2018

1 reference

Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins

21 January 2018

1 reference

Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions

21 January 2018

1 reference

Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.

21 January 2018

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Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.

21 January 2018

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Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

21 January 2018

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NEMO oligomerization and its ubiquitin-binding properties

21 January 2018

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A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation

21 January 2018

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Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

21 January 2018

1 reference

New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein

21 January 2018

1 reference

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

21 January 2018

1 reference

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

21 January 2018

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Essential function for the kinase TAK1 in innate and adaptive immune responses

21 January 2018

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Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.

21 January 2018

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Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

21 January 2018

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

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Direct activation of protein kinases by unanchored polyubiquitin chains

21 January 2018

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A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

21 January 2018

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Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses

21 January 2018

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A ubiquitin ligase complex assembles linear polyubiquitin chains

21 January 2018

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Linear ubiquitination prevents inflammation and regulates immune signalling

21 January 2018

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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

21 January 2018

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

21 January 2018

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LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

21 January 2018

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

21 January 2018

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Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

21 January 2018

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Novel cross-talk within the IKK family controls innate immunity

21 January 2018

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Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

21 January 2018

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Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

21 January 2018

1 reference

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

21 January 2018

1 reference

Signal processing by its coil zipper domain activates IKK gamma

21 January 2018

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DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

21 January 2018

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NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα.

21 January 2018

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A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha

21 January 2018

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Regulation and function of IKK and IKK-related kinases

21 January 2018

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NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

21 January 2018

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SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK

21 January 2018

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Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling

21 January 2018

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Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

21 January 2018

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Functional dissection of the TBK1 molecular network

21 January 2018

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Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases

21 January 2018

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The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways

21 January 2018

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The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling

21 January 2018

1 reference

The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling

21 January 2018

1 reference

TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

21 January 2018

1 reference

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

21 January 2018

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Triggering the interferon antiviral response through an IKK-related pathway

21 January 2018

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Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3

21 January 2018

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NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.

21 January 2018

1 reference

Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

21 January 2018

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Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.

21 January 2018

1 reference

Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex

21 January 2018

1 reference

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

21 January 2018

1 reference

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

21 January 2018

1 reference

A20 is a negative regulator of IFN regulatory factor 3 signaling.

21 January 2018

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In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase

21 January 2018

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Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity

21 January 2018

1 reference

Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation

21 January 2018

1 reference

Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta

21 January 2018

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Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo

21 January 2018

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Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 January 2018

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A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

21 January 2018

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

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Structure of the A20 OTU domain and mechanistic insights into deubiquitination

21 January 2018

1 reference

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity

21 January 2018

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Direct, noncatalytic mechanism of IKK inhibition by A20.

21 January 2018

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Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

21 January 2018

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A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

21 January 2018

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Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.

21 January 2018

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The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN

21 January 2018

1 reference

ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB

21 January 2018

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Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

21 January 2018

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Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

21 January 2018

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ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling

21 January 2018

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Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

21 January 2018

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ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

21 January 2018

1 reference

A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease

21 January 2018

1 reference

ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability

21 January 2018

1 reference

IkappaB kinase is an essential component of the Tpl2 signaling pathway

21 January 2018

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Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.

21 January 2018

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ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

21 January 2018

1 reference

p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

21 January 2018

1 reference

LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation

21 January 2018

1 reference

ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions

21 January 2018

1 reference

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

21 January 2018

1 reference

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

21 January 2018

1 reference

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone

21 January 2018

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Adult-onset primary open-angle glaucoma caused by mutations in optineurin

21 January 2018

1 reference

Confirmation of TBK1 duplication in normal tension glaucoma

21 January 2018

1 reference

Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity

21 January 2018

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The IKK complex, a central regulator of NF-kappaB activation

21 January 2018

1 reference

Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation

21 January 2018

1 reference

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

21 January 2018

1 reference

Psoriasis bench to bedside: genetics meets immunology

21 January 2018

1 reference

Investigation of 20 non-HLA (human leucocyte antigen) psoriasis susceptibility loci in Chinese patients with psoriatic arthritis and psoriasis vulgaris

21 January 2018

1 reference

Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08

21 January 2018

1 reference

A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma.

21 January 2018

1 reference

Mutations of optineurin in amyotrophic lateral sclerosis

21 January 2018

1 reference

Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

21 January 2018

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Constructing and decoding unconventional ubiquitin chains.

21 January 2018

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OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

21 January 2018

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The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

21 January 2018

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The noncanonical NF-κB pathway

21 January 2018

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Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

21 January 2018

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TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

21 January 2018

1 reference

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

21 January 2018

1 reference

TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population

31 March 2020

1 reference

Catlysis of the phosphrylaseinase actition reaction

31 March 2020

1 reference

12 December 2020

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

1 reference

12 December 2020

The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B

1 reference

12 December 2020

ABIN1 dysfunction as a genetic basis for lupus nephritis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM3644

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Dimensions Publication ID

29 August 2017

1028780617

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