(Q37957147)

25 August 2017

title

Targeting post-translational modifications on tau as a therapeutic strategy for Alzheimer's disease (English)

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25 August 2017

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Jacob Newman Marcus

1

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25 August 2017

Joel Schachter

series ordinal

2

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25 August 2017

publication date

1 December 2011

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25 August 2017

published in

Journal of Neurogenetics

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25 August 2017

volume

25

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25 August 2017

issue

4

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25 August 2017

page(s)

127-133

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Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration

25 August 2017

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The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

21 January 2018

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Staging of Alzheimer's disease-related neurofibrillary changes

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D-Ribosylated Tau forms globular aggregates with high cytotoxicity

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An overview of APP processing enzymes and products

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

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O-GlcNAc modification in diabetes and Alzheimer's disease

21 January 2018

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Does my mouse have Alzheimer's disease?

21 January 2018

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Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

21 January 2018

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Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

21 January 2018

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Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

21 January 2018

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Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

21 January 2018

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

21 January 2018

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

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Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics

21 January 2018

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21 January 2018

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Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

21 January 2018

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

21 January 2018

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Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

21 January 2018

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Splicing factor SC35 promotes tau expression through stabilization of its mRNA

21 January 2018

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Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

21 January 2018

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A possible link between astrocyte activation and tau nitration in Alzheimer's disease.

21 January 2018

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Site-specific nitration differentially influences tau assembly in vitro

21 January 2018

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21 January 2018

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Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies.

21 January 2018

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Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases

21 January 2018

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Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

Glycosylation of microtubule-associated protein tau in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

O-GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

Structural Study onO-Glycopeptides: Glycosylation-Induced Conformational Changes ofO-GlcNAc,O-LacNAc,O-Sialyl-LacNAc, andO-Sialyl-Lewis-X Peptides of the Mucin Domain of MAdCAM-1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.626471

10.3109/01677063.2011.626471

21 January 2018

Identifiers

DOI

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25 August 2017

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