(Q37684794)

22 August 2017

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title

Antiplatelet therapies for the treatment of cardiovascular disease (English)

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22 August 2017

main subject

cardiovascular disease

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Alan D Michelson

1

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22 August 2017

publication date

1 February 2010

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Nature Reviews Drug Discovery

22 August 2017

published in

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22 August 2017

volume

9

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22 August 2017

issue

2

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22 August 2017

page(s)

154-169

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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

22 August 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Interaction between cigarette smoking and clinical benefit of clopidogrel

31 March 2020

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Cytochrome p-450 polymorphisms and response to clopidogrel

31 March 2020

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Genetic determinants of response to clopidogrel and cardiovascular events

31 March 2020

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Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

31 March 2020

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Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance'

31 March 2020

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Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting.

31 March 2020

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High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability.

31 March 2020

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The difference between clopidogrel responsiveness and posttreatment platelet reactivity

31 March 2020

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Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity

31 March 2020

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Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment

31 March 2020

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Thrombosis and drug-eluting stents: an objective appraisal

31 March 2020

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Prasugrel: a novel thienopyridine antiplatelet agent. A review of preclinical and clinical studies and the mechanistic basis for its distinct antiplatelet profile

31 March 2020

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The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite

31 March 2020

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A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation

31 March 2020

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Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease

31 March 2020

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Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel

31 March 2020

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Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myoc

31 March 2020

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Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial

31 March 2020

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Prasugrel versus clopidogrel in patients with acute coronary syndromes

31 March 2020

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Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial

31 March 2020

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Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocar

31 March 2020

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Preclinical and clinical studies with selective reversible direct P2Y12 antagonists

31 March 2020

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Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin

31 March 2020

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Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSE

31 March 2020

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Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes

31 March 2020

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Ticagrelor versus clopidogrel in patients with acute coronary syndromes

31 March 2020

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Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial

31 March 2020

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αIIbβ3 (GPIIb-IIIa) Antagonists

31 March 2020

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An Abnormal Platelet Glycoprotein Pattern in Three Cases of Glanzmann's Thrombasthenia

31 March 2020

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Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics

31 March 2020

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In vitro effects of the platelet glycoprotein IIb/IIIa receptor antagonist c7E3 Fab on the activated clotting time

31 March 2020

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Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis".

31 March 2020

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Networking in the hemostatic system. Integrin alphaiibbeta3 binds prothrombin and influences its activation

31 March 2020

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Glycoprotein IIb/IIIa receptor inhibitors in 2008: do they still have a role?

31 March 2020

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Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a meta-analysis of phase III multicenter randomized trials

31 March 2020

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Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

31 March 2020

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Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen.

31 March 2020

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Antiaggregatory and proangiogenic effects of a novel recombinant human dual specificity anti-integrin antibody

31 March 2020

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Targeting ligand-induced binding sites on GPIIb/IIIa via single-chain antibody allows effective anticoagulation without bleeding time prolongation

31 March 2020

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European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke

31 March 2020

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Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial

31 March 2020

1 reference

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke

31 March 2020

1 reference

Systematic review and meta-analysis of randomized clinical trials appraising the impact of cilostazol after percutaneous coronary intervention

31 March 2020

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Comparison of triple versus dual antiplatelet therapy after drug-eluting stent implantation (from the DECLARE-Long trial)

31 March 2020

1 reference

A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study.

31 March 2020

1 reference

Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study

31 March 2020

1 reference

A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor gamma-chain complex

31 March 2020

1 reference

Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism

31 March 2020

1 reference

In Vivo Antithrombotic Effects of a Nitric Oxide-Releasing Aspirin Derivative, NCX-4016

31 March 2020

1 reference

Functional effects of nitric oxide-releasing aspirin on vein conduits of diabetic patients undergoing CABG

31 March 2020

1 reference

The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons.

31 March 2020

1 reference

Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin

31 March 2020

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Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model

31 March 2020

1 reference

Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis

31 March 2020

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Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation

31 March 2020

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Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism

31 March 2020

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Antithrombotic effects of S 18886, a novel orally active thromboxane A2 receptor antagonist

31 March 2020

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Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirin

31 March 2020

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The specific thromboxane receptor antagonist S18886: pharmacokinetic and pharmacodynamic studies.

31 March 2020

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Distinct effects of z-335, a new thromboxane A2 receptor antagonist, on rabbit platelets and aortic smooth muscle

31 March 2020

1 reference

The Thromboxane Receptor Antagonist PBT-3, a Hepoxilin Stable Analog, Selectively Antagonizes the TPα Isoform in Transfected COS-7 Cells

31 March 2020

1 reference

Effects of selective cyclooxygenase inhibitors on ischemia/reperfusion-induced hepatic microcirculatory dysfunction in mice

31 March 2020

1 reference

Augmented contraction of the human isolated coronary artery by sumatriptan: a possible role for endogenous thromboxane

31 March 2020

1 reference

Thromboxane A2 receptor density increases during chronic exposure to thromboxane A2 receptor antagonists after porcine carotid bypass

31 March 2020

1 reference

Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study

31 March 2020

1 reference

Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function

31 March 2020

1 reference

Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion

31 March 2020

1 reference

Antiaggregating and vasodilatory effects of a new nitroderivative of acetylsalicylic acid

31 March 2020

1 reference

Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding

31 March 2020

1 reference

Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3).

31 March 2020

1 reference

Advantages of a selective beta-isoform phosphoinositide 3-kinase antagonist, an anti-thrombotic agent devoid of other cardiovascular actions in the rat.

31 March 2020

1 reference

Discovery-based strategies for studying platelet function

31 March 2020

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Platelet membrane proteomics: a novel repository for functional research

31 March 2020

1 reference

Methods for the measurement of platelet function

31 March 2020

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Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists

31 March 2020

1 reference

Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel

31 March 2020

1 reference

Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes

31 March 2020

1 reference

Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosis

31 March 2020

1 reference

Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: a prospective, randomized study.

31 March 2020

1 reference

Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention: results from the double-blind, prospective, randomized Tailoring Treatment with Tirofiban in Patien

31 March 2020

1 reference

The Glycoprotein Ib-IX-V Complex

31 March 2020

1 reference

P-Selectin/PSGL-1 and Other Interactions between Platelets, Leukocytes, and Endothelium

31 March 2020

1 reference

Coagulation 2006: a modern view of hemostasis.

31 March 2020

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Mechanisms of thrombus formation

31 March 2020

1 reference

A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease

31 March 2020

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GPIIb-IIIa antagonist-induced reduction in platelet surface factor V/Va binding and phosphatidylserine expression in whole blood

31 March 2020

1 reference

12 December 2020

Cardioprotective actions of the specific thromboxane receptor antagonist (+)-S145Na following coronary occlusion and reperfusion in the rat.

1 reference

12 December 2020

Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes

1 reference

12 December 2020

A snake venom metalloproteinase, kistomin, cleaves platelet glycoprotein VI and impairs platelet functions

1 reference

12 December 2020

Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis.

1 reference

12 December 2020

Preliminary clinical studies with thromboxane synthase inhibitors and thromboxane receptor blockers. A review

1 reference

12 December 2020

Platelets and wound healing

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD2957

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22 August 2017

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