(Q37243937)

19 August 2017

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title

Molecular pathogenesis of bladder cancer (English)

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19 August 2017

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1

Margaret A Knowles

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publication date

15 August 2008

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International Journal of Clinical Oncology

19 August 2017

published in

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19 August 2017

volume

13

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19 August 2017

issue

4

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19 August 2017

page(s)

287-297

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Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors

19 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS10147-008-0812-0

Ras and phosphoinositide 3-kinase: partners in development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10147-008-0812-0

Amplification and over-expression of c-erbB-2 in transitional cell carcinoma of the urinary bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10147-008-0812-0

Patterns of chromosomal imbalances in advanced urinary bladder cancer detected by comparative genomic hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10147-008-0812-0

Frequent genetic alterations in simple urothelial hyperplasias of the bladder in patients with papillary urothelial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10147-008-0812-0

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms

21 January 2018

1 reference

12 December 2020

PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors.

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12 December 2020

Inverted papilloma of the urinary bladder: a molecular genetic appraisal

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12 December 2020

FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer

1 reference

12 December 2020

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.

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12 December 2020

Prognostic value of amplification of c-erb-B2 in bladder carcinoma

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12 December 2020

Chromosomal imbalances are associated with a high risk of progression in early invasive (pT1) urinary bladder cancer

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12 December 2020

Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.

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12 December 2020

Ha-ras codon 12 mutation in papillary tumors of the urinary-bladder - a retrospective study

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12 December 2020

An immunohistologic evaluation of C-erbB-2 gene product in patients with urinary bladder carcinoma

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12 December 2020

Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder.

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12 December 2020

Statistical behavior of complex cancer karyotypes

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12 December 2020

Combined effects of p53, p21, and pRb expression in the progression of bladder transitional cell carcinoma

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12 December 2020

Chromosome 9 deletions and recurrence of superficial bladder cancer: identification of four regions of prognostic interest

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12 December 2020

Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage

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12 December 2020

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

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12 December 2020

Mutation of the 9q34 gene TSC1 in sporadic bladder cancer

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12 December 2020

Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma

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12 December 2020

Hypermethylation at 9q32-33 tumour suppressor region is age-related in normal urothelium and an early and frequent alteration in bladder cancer

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12 December 2020

Inactivation of MMAC1 in bladder transitional-cell carcinoma cell lines and specimens

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12 December 2020

Homozygous deletion mapping at 9p21 in bladder carcinoma defines a critical region within 2cM of IFNA

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12 December 2020

Molecular evolution of multiple recurrent cancers of the bladder

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12 December 2020

E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer

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12 December 2020

Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q.

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12 December 2020

Cytogenetic analysis of multifocal bladder cancer supports a monoclonal origin and intraepithelial spread of tumor cells

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12 December 2020

Altered patterns of MDM2 and TP53 expression in human bladder cancer

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12 December 2020

Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing

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12 December 2020

Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract.

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12 December 2020

Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

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12 December 2020

Alteration of the PATCHED locus in superficial bladder cancer

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12 December 2020

FGFR3 and Tp53 Mutations in T1G3 Transitional Bladder Carcinomas: Independent Distribution and Lack of Association with Prognosis

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12 December 2020

Splice variants but not mutations of DNA polymerase beta are common in bladder cancer

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12 December 2020

FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder

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12 December 2020

Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro

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12 December 2020

Amplification at chromosome 11q13 in transitional cell tumours of the bladder.

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12 December 2020

Amplification and overexpression of E2F3 in human bladder cancer

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12 December 2020

p53 mutations and prognosis in bladder tumors

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12 December 2020

Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas.

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12 December 2020

Loss of heterozygosity at chromosome segments 8p22 and 8p11.2-21.1 in transitional-cell carcinoma of the urinary bladder

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12 December 2020

Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification.

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12 December 2020

Role of E2F3 expression in modulating cellular proliferation rate in human bladder and prostate cancer cells

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12 December 2020

Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder

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12 December 2020

Identification of cytogenetic subgroups and karyotypic pathways in transitional cell carcinoma

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12 December 2020

Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer.

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12 December 2020

Identification of H-ras mutations in urine sediments complements cytology in the detection of bladder tumors

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12 December 2020

FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma

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12 December 2020

Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27.

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12 December 2020

Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer

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12 December 2020

Bladder cancer stage and outcome by array-based comparative genomic hybridization

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12 December 2020

Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer

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12 December 2020

Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors

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12 December 2020

High-throughput tissue microarray analysis of 11q13 gene amplification (CCND1, FGF3, FGF4, EMS1) in urinary bladder cancer

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12 December 2020

Patterns of chromosomal imbalances in muscle invasive bladder cancer

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12 December 2020

E2F3 is the main target gene of the 6p22 amplicon with high specificity for human bladder cancer

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12 December 2020

Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB-1 is superior to pathologic grade for the prediction of clinical outcome

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12 December 2020

Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.

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12 December 2020

Effect of p21WAF1/CIP1 expression on tumor progression in bladder cancer

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12 December 2020

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

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12 December 2020

The p53 Pathway and Outcome among Patients with T1G3 Bladder Tumors

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12 December 2020

Initiation of bladder cancer may involve deletion of a tumour-suppressor gene on chromosome 9.

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12 December 2020

p53 gene and protein status: the role of p53 alterations in predicting outcome in patients with bladder cancer

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12 December 2020

Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors.

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12 December 2020

Nonrandom chromosomal changes in transitional cell carcinoma of the bladder

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12 December 2020

Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33.

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12 December 2020

Altered Expression of Retinoblastoma Protein and Known Prognostic Variables in Locally Advanced Bladder Cancer

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12 December 2020

Rates of p16 (MTS1) mutations in primary tumors with 9p loss

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12 December 2020

Infrequent mutation of TRAIL receptor 2 (TRAIL-R2/DR5) in transitional cell carcinoma of the bladder with 8p21 loss of heterozygosity.

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12 December 2020

Evidence for two bladder cancer suppressor loci on human chromosome 9

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12 December 2020

Detecting homozygous deletions in the CDKN2A(p16(INK4a))/ARF(p14(ARF)) gene in urinary bladder cancer using real-time quantitative PCR.

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12 December 2020

Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization

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12 December 2020

A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC.

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12 December 2020

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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12 December 2020

Genetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer

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12 December 2020

Characterization of chromosome 9 deletions in transitional cell carcinoma by microsatellite assay

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12 December 2020

Expression of cyclin D1 and EMS1 in bladder tumours; relationship with chromosome 11q13 amplification

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12 December 2020

PTCH gene mutations in invasive transitional cell carcinoma of the bladder

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12 December 2020

Somatic mutation of PTEN in bladder carcinoma

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12 December 2020

Heterogeneity of erbB-2 gene amplification in bladder cancer

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12 December 2020

Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer

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12 December 2020

FrequentFGFR3mutations in urothelial papilloma

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12 December 2020

Deletion of the p16 and p15 Genes in Human Bladder Tumors

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12 December 2020

DBC1 re-expression alters the expression of multiple components of the plasminogen pathway.

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12 December 2020

Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction

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12 December 2020

Progressive increases in de novo methylation of CpG islands in bladder cancer.

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12 December 2020

The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate

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12 December 2020

Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression

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12 December 2020

Comprehensive analysis of CDKN2A status in microdissected urothelial cell carcinoma reveals potential haploinsufficiency, a high frequency of homozygous co-deletion and associations with clinical phenotype.

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12 December 2020

Altered expression of the retinoblastoma gene product: prognostic indicator in bladder cancer

1 reference

12 December 2020

Pathways of urothelial cancer progression suggested by Bayesian network analysis of allelotyping data

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12 December 2020

Karyotypic characterization of urinary bladder transitional cell carcinomas

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12 December 2020

Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers

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12 December 2020

HER-2 and TOP2A coamplification in urinary bladder cancer

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12 December 2020

C-ERBB-2 gene amplification as a prognostic marker in human bladder cancer

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12 December 2020

Mutation analysis of 8p genes POLB and PPP2CB in bladder cancer

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12 December 2020

Two molecular pathways to transitional cell carcinoma of the bladder.

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12 December 2020

The IARC TP53 database: new online mutation analysis and recommendations to users

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12 December 2020

Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer

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12 December 2020

Deletion mapping implicates two tumor suppressor genes on chromosome 8p in the development of bladder cancer

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12 December 2020

Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH, and FISH analyses

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12 December 2020

p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer

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12 December 2020

Identification of p53 gene mutations in bladder cancers and urine samples

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12 December 2020

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

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12 December 2020

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

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12 December 2020

Genetic alterations in primary bladder cancers and their metastases.

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12 December 2020

Frequent association of p53 gene mutation in invasive bladder cancer

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12 December 2020

Cluster of allele losses within a 2.5 cM region of chromosome 10 in high-grade invasive bladder cancer

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12 December 2020

Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.

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12 December 2020

Chromosomal imbalances in noninvasive papillary bladder neoplasms (pTa)

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12 December 2020

Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer

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12 December 2020

Tree models for dependent copy number changes in bladder cancer

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12 December 2020

Definition of two regions of deletion on chromosome 9 in carcinoma of the bladder.

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12 December 2020

Accelerated induction of bladder cancer in patched heterozygous mutant mice

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12 December 2020

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma

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12 December 2020

p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer

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12 December 2020

Loss of heterozygosity analysis and DNA copy number measurement on 8p in bladder cancer reveals two mechanisms of allelic loss.

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12 December 2020

Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification.

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12 December 2020

Natural history of urothelial inverted papilloma

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12 December 2020

Clonal and chronological genetic analysis of multifocal cancers of the bladder and upper urinary tract

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12 December 2020

Deletion mapping of chromosome 11 in carcinoma of the bladder.

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12 December 2020

Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma.

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12 December 2020

PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity

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12 December 2020

10.1007/S10147-008-0812-0

Identifiers

DOI

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19 August 2017

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