(Q37219529)

19 August 2017

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title

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies (English)

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19 August 2017

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S Sarkar

1

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19 August 2017

B Ravikumar

series ordinal

2

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19 August 2017

R A Floto

series ordinal

3

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19 August 2017

D C Rubinsztein

series ordinal

4

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19 August 2017

publication date

18 July 2008

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Cell Death & Differentiation

19 August 2017

published in

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19 August 2017

volume

16

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19 August 2017

issue

1

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19 August 2017

page(s)

46-56

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Autophagy fights disease through cellular self-digestion

19 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Autophagosome formation: core machinery and adaptations

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7 January 2021

Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes

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7 January 2021

Development by self-digestion: molecular mechanisms and biological functions of autophagy

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https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Molecular dissection of autophagy: two ubiquitin-like systems

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https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

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https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Potential therapeutic applications of autophagy

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Self-eating and self-killing: crosstalk between autophagy and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Protein aggregation and neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Polyglutamine diseases: emerging concepts in pathogenesis and therapy

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Opinion: What is the role of protein aggregation in neurodegeneration?

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

The roles of intracellular protein-degradation pathways in neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Rapamycin alleviates toxicity of different aggregate-prone proteins

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Lithium delays progression of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Rapamycin pre-treatment protects against apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Lithium induces autophagy by inhibiting inositol monophosphatase

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Small molecule regulators of autophagy identified by an image-based high-throughput screen

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Growing roles for the mTOR pathway

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

A common mechanism of action for three mood-stabilizing drugs

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Inositol trisphosphate and calcium signalling

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Regulation of autophagy by the inositol trisphosphate receptor

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Neural and developmental actions of lithium: a unifying hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Lithium neuroprotection: molecular mechanisms and clinical implications

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Valproate decreases inositol biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Calcium channel antagonists: clinical uses--past, present and future

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Short-term stimulation by propranolol and verapamil of cardiac cellular autophagy

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

https://api.crossref.org/works/10.1038%2FCDD.2008.110

1 reference

7 January 2021

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Inhibition of cAMP production by α2-adrenoceptor stimulation in rabbit retina

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

cAMP effector mechanisms. Novel twists for an 'old' signaling system

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Phospholipase C(epsilon): a novel Ras effector

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Excitotoxicity in Huntington disease

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Calpain activation in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.110

7 January 2021

Identifiers

DOI

10.1038/CDD.2008.110

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Dimensions Publication ID

19 August 2017

1018155670

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1 reference