(Q37055845)

18 August 2017

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title

Molecular biology of the myocardial Na+/H+ exchanger (English)

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18 August 2017

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Larry Fliegel

1

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18 August 2017

publication date

7 December 2007

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Journal of Molecular and Cellular Cardiology

18 August 2017

published in

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18 August 2017

volume

44

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18 August 2017

issue

2

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18 August 2017

page(s)

228-237

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Comparative molecular analysis of Na+/H+ exchangers: a unified model for Na+/H+ antiport?

18 August 2017

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Identification of the protein and cDNA of the cardiac Na+/H+ exchanger

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Cloning and analysis of the human myocardial Na+/H+ exchanger

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Quantitation of plasma membrane expression of a fusion protein of Na/H exchanger NHE3 and green fluorescence protein (GFP) in living PS120 fibroblasts

7 January 2021

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Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain

7 January 2021

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Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain

7 January 2021

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Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3

7 January 2021

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Presence of the NHE3 isoform of the Na+/H+ exchanger in human gallbladder

7 January 2021

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Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation

7 January 2021

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Identification of a mitochondrial Na+/H+ exchanger

7 January 2021

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Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria

7 January 2021

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Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network

7 January 2021

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The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing"

7 January 2021

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A novel topology model of the human Na(+)/H(+) exchanger isoform 1

7 January 2021

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The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain

7 January 2021

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Multiple carbohydrate moieties on the Na+/H+ exchanger

7 January 2021

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Na(+)/H(+) exchanger NHE3 has 11 membrane spanning domains and a cleaved signal peptide: topology analysis using in vitro transcription/translation.

7 January 2021

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NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell

7 January 2021

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Characterization of the placental brush border membrane Na+/H+ exchanger: identification of thiol-dependent transitions in apparent molecular size

7 January 2021

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Dimeric interaction between the cytoplasmic domains of the Na+/H+ exchanger NHE1 revealed by symmetrical intermolecular cross-linking and selective co-immunoprecipitation

7 January 2021

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Coupling of lithium to sodium transport in human red cells

7 January 2021

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Sodium-lithium countertransport in erythrocytes of hypertension prone families in Utah

7 January 2021

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Elevated sodium-lithium countertransport activity in erythrocytes is predictive of the development of microalbuminuria in IDDM.

7 January 2021

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7 January 2021

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Fibroblast Na+-Li+ countertransport rate is elevated in essential hypertension

7 January 2021

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Difference between human red blood cell Na+-Li+ countertransport and renal Na+-H+ exchange

7 January 2021

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Alternative splicing of NHE-1 mediates Na-Li countertransport and associates with activity rate

7 January 2021

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Structural and functional analysis of the Na+/H+ exchanger

7 January 2021

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Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension

7 January 2021

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Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1

7 January 2021

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Delineation of transmembrane domains of the Na+/H+ exchanger that confer sensitivity to pharmacological antagonists

7 January 2021

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A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis

7 January 2021

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Second-site revertants of a low-sodium-affinity mutant of the Na+/H+ exchanger reveal the participation of TM4 into a highly constrained sodium-binding site

7 January 2021

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Identification of sites in the second exomembrane loop and ninth transmembrane helix of the mammalian Na+/H+ exchanger important for drug recognition and cation translocation.

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger

7 January 2021

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Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1.

7 January 2021

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Functional characterization of the transmembrane segment VII of the NHE1 isoform of the Na+/H+ exchanger

7 January 2021

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Mutations of Arg440 and Gly455/Gly456 oppositely change pH sensing of Na+/H+ exchanger 1.

7 January 2021

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Protein kinase-mediated regulation of the Na(+)/H(+) exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways

7 January 2021

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Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury

7 January 2021

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Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway.

7 January 2021

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Mitogen-activated protein kinase-dependent activation of the Na+/H+ exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771.

7 January 2021

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Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium

7 January 2021

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Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers

7 January 2021

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Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger

7 January 2021

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Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.

7 January 2021

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The Carboxyl-Terminal Region of the Na+/H+ Exchanger Interacts with Mammalian Heat Shock Protein

7 January 2021

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Na+-H+ exchange activity in renal brush border membrane vesicles in response to metabolic acidosis: The role of glucocorticoids

7 January 2021

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Functional adaptation to high PCO2 of apically and basolaterally located Na+/H+ exchange activities in cultured renal cell lines

7 January 2021

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Expression of rat renal Na/H antiporter mRNA levels in response to respiratory and metabolic acidosis

7 January 2021

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Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts

7 January 2021

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Enhanced Na(+)-H+ exchanger activity and NHE-1 mRNA levels in human lymphocytes during metabolic acidosis

7 January 2021

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Induction of expression of the sodium-hydrogen exchanger in rat myocardium

7 January 2021

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Differential effects of angiotensin AT1 and AT2 receptors on the expression, translation and function of the Na+-H+ exchanger and Na+-HCO3- symporter in the rat heart after myocardial infarction

7 January 2021

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Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na(+)/H(+) exchanger

7 January 2021

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Regression of hypertensive myocardial fibrosis by Na(+)/H(+) exchange inhibition

7 January 2021

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Regression of isoproterenol-induced cardiac hypertrophy by Na+/H+ exchanger inhibition

7 January 2021

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Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target

7 January 2021

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Aldosterone Increases NHE-1 Expression and Induces NHE-1-Dependent Hypertrophy in Neonatal Rat Ventricular Myocytes

7 January 2021

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Stretch-induced alkalinization of feline papillary muscle: an autocrine-paracrine system

7 January 2021

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pHi regulation in myocardium of the spontaneously hypertensive rat. Compensated enhanced activity of the Na(+)-H+ exchanger

7 January 2021

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Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy

7 January 2021

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Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers

7 January 2021

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Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload

7 January 2021

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Na(+)influx via Na(+)/H(+)exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes

7 January 2021

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Sodium restriction prevents cardiac hypertrophy and oxidative stress in angiotensin II hypertension

7 January 2021

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Antihypertrophic effect of Na+/H+ exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen speci

7 January 2021

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Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na+/H+ exchanger-1 (NHE-1) inhibition

7 January 2021

1 reference

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Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2007.11.016

Diabetes-induced vascular hypertrophy is accompanied by activation of Na(+)-H(+) exchange and prevented by Na(+)-H(+) exchange inhibition

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2007.11.016

Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expression

7 January 2021

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Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload

7 January 2021

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Cardiac Na+-H+ exchanger during postnatal development in the rat: changes in mRNA expression and sarcolemmal activity

7 January 2021

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Developmental changes in mRNA encoding cardiac Na+/H+ exchanger (NHE-1) in rabbit

7 January 2021

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Phylogenetically conserved sequences in the promoter of the rabbit sodium-hydrogen exchanger isoform 1 gene (NHE1/SLC9A1).

7 January 2021

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Structural study of the porcine Na+/H+ exchanger NHE1 gene and its 5'-flanking region.

7 January 2021

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Activation of the Na+/H+ exchanger gene by the transcription factor AP-2.

7 January 2021

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Structure and analysis of the mouse Na+/H+ exchanger (NHE1) gene: homology and conservation of splice sites

7 January 2021

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Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity

7 January 2021

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Role of C/EBP proteins in hepatic and vascular smooth muscle transcription of human NHE1 gene

7 January 2021

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Regulation of NHE1 expression in L6 muscle cells

7 January 2021

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Specific activation of the Na+/H+ exchanger gene during neuronal differentiation of embryonal carcinoma cells

7 January 2021

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Regulation of Na+/H+ exchanger gene expression. Role of a novel poly(dA.dT) element in regulation of the NHE1 promoter

7 January 2021

1 reference

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COUP-TFI and COUP-TFII regulate expression of the NHE through a nuclear hormone responsive element with enhancer activity

7 January 2021

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Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1)

7 January 2021

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Identification of an HMG-like protein involved in regulation of Na+/H+ exchanger expression

7 January 2021

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Cardiac oxidative stress in acute and chronic isoproterenol-infused rats

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2007.11.016

Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2007.11.016

Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2007.11.016

Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced beta-myosin heavy chain gene expression and cardiomyocyte hypertrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2007.11.016

Reactive oxygen species-mediated regulation of the Na+-H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2007.11.016

Oxidative repression of NHE1 gene expression involves iron-mediated caspase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2007.11.016

Transcriptional regulation of Na+/H+ exchanger expression in the intact mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2007.11.016

10.1016/J.YJMCC.2007.11.016

7 January 2021

Identifiers

DOI

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18 August 2017

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