(Q36716615)

15 August 2017

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title

Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease (English)

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15 August 2017

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Fleisch H

1

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15 August 2017

publication date

1 December 1991

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15 August 2017

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15 August 2017

volume

42

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15 August 2017

issue

6

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15 August 2017

page(s)

919-944

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Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: the effect of a bisphosphonate.

15 August 2017

cites work

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12 December 2020

Development of an acute model for the study of chloromethanediphosphonate nephrotoxicity

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12 December 2020

Clodronate treatment in patients with malignancy-associated hypercalcemia

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12 December 2020

Role of bone and kidney in tumor-induced hypercalcemia and its treatment with bisphosphonate and sodium chloride

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12 December 2020

The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis

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12 December 2020

Neoplastic hypercalcemia: physiologic response to intravenous etidronate disodium

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12 December 2020

[Treatment of hypercalcemia of tumoral origin with two diphosphonates]

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12 December 2020

Intestinal absorption of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) using a deconvolution technique.

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12 December 2020

Bone and renal components in hypercalcemia of malignancy and responses to a single infusion of clodronate

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12 December 2020

Effects of dichloromethylene diphosphonate on skeletal mobilization of calcium in multiple myeloma

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12 December 2020

Aggregation of hydroxyapatite crystals

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12 December 2020

Comparison of three intravenous bisphosphonates in cancer-associated hypercalcaemia

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12 December 2020

Effects of a new aminodiphosphonate (aminohydroxybutylidene diphosphonate) in patients with osteolytic lesions from metastases and myelomatosis. Comparison with dichloromethylene diphosphonate.

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12 December 2020

Effects of 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) on the synthesis of dentin matrix proteins in the mouse

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12 December 2020

Changes in the renal and extrarenal handling of phosphate induced by disodium etidronate (EHDP) in man.

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12 December 2020

Treatment of malignancy-associated hypercalcemia with intravenous aminohydroxypropylidene diphosphonate

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12 December 2020

The influence of multidentate organic phosphonates on the crystal growth of hydroxyapatite

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12 December 2020

Intravenous disodium etidronate therapy in Paget's disease of bone and hypercalcemia of malignancy. Effects on biochemical parameters and bone histomorphometry

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12 December 2020

Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix

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12 December 2020

Renal handling of calcium and sodium in metastatic and non-metastatic malignancy

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12 December 2020

Effects of disodium etidronate in murine tumor models

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12 December 2020

Clodronate kinetics and bioavailability

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12 December 2020

Inhibition by diphosphonates of bone resorption in mice and comparison with grey-lethal osteopetrosis

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12 December 2020

Fast (4-h) or slow (24-h) infusions of pamidronate disodium (aminohydroxypropylidene diphosphonate (APD)) as single shot treatment of hypercalcaemia

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12 December 2020

An experimental rat model of local bone cancer invasion and its responsiveness to ethane-1-hydroxy-1,1-bis(phosphonate)

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12 December 2020

The effect of dichloromethylene diphosphonate, a pyrophosphate analog, on bone and bone cell structure in the growing rat

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12 December 2020

Dichloromethylene diphosphonate (Cl2MDP) reduces natural killer (NK) cell activity in mice

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12 December 2020

Uptake by Bone of Pyrophosphate, Diphosphonates and their Technetium Derivatives

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12 December 2020

Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages

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12 December 2020

A method for continual monitoring of bone resorption in rats: evidence for a diurnal rhythm

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12 December 2020

Distribution of [14C]clodronate (dichloromethylene bisphosphonate) disodium in mice

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12 December 2020

Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkey

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12 December 2020

Role of bone and kidney in parathyroid hormone-related peptide-induced hypercalcemia in rats

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12 December 2020

Comparison of different dose regimes of aminohydroxypropylidene-1,1-bisphosphonate (APD) in hypercalcaemia of malignancy

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12 December 2020

Clodronate therapy of metastatic bone disease in patients with prostatic carcinoma

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12 December 2020

Dose-response in the treatment of hypercalcemia of malignancy by a single infusion of the bisphosphonate AHPrBP

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12 December 2020

The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hypercalcemia of malignancy in the rat leydig cell tumor

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12 December 2020

Effects of dichloromethylene diphosphonate on the osteolytic and osteoplastic effects of rat prostate adenocarcinoma cells

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12 December 2020

Inhibition of osteolytic bone lesions by (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.)

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12 December 2020

Inhibition by two diphosphonates of bone lysis in tumor-conditioned media

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12 December 2020

Clodronate kinetics and dynamics

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12 December 2020

The effects of dichloromethylene biphosphonate on osteoporotic femora of adult castrate male rats

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12 December 2020

Aminohydroxypropylidene bisphosphonate (APD) treatment for tumor-associated hypercalcemia: a randomized comparison between a 3-day treatment and single 24-hour infusions

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12 December 2020

Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy

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12 December 2020

Parathyroid hormone and renal handling of Pi: effect of dietary Pi and diphosphonates

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12 December 2020

The use of dichloromethylene bisphosphonate and aminobutane bisphosphonate in hypercalcemia of malignancy

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12 December 2020

Acute intravenous infusion of disodium dihydrogen (1-hydroxyethylidene)diphosphonate: mechanism of toxicity

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12 December 2020

A single-day treatment of tumor-induced hypercalcemia by intravenous amino-hydroxypropylidene bisphosphonate

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12 December 2020

Renal failure associated with intravenous diphosphonates

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12 December 2020

Treatment of bone metastases from breast cancer with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD).

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12 December 2020

Ileal absorption of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) and disodium dichloromethylene diphosphonate(C12 MDP) in the chick

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12 December 2020

Lack of a T-cell dependent subpopulation of macrophages in (dichloromethylene) diphosphonate-treated mice

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12 December 2020

Bisphosphonates in vitro specifically inhibit, among the hematopoietic series, the development of the mouse mononuclear phagocyte lineage

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12 December 2020

Diphosphonates are potent inhibitors of mammalian inorganic pyrophosphatase.

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12 December 2020

Treatment of skeletal disease in breast cancer: a controlled clodronate trial

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12 December 2020

Treatment of hypercalcemia of malignancy with intravenous etidronate. A controlled, multicenter study. The Hypercalcemia Study Group

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12 December 2020

Effect of Disodium Ethane-l-Hydroxy-1, 1 - Diphosphonate on Bone Formation

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12 December 2020

Bone invasion by Walker 256 carcinoma, line A in young and adult rats: effects of etidronate

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12 December 2020

Preliminary safety assessment of disodium etidronate as an additive to experimental oral hygiene products

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12 December 2020

Effect of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) and dichloromethylidene-bisphosphonate (Cl2MBP) on the structure of the organic matrix of heterotopically induced bone tissue.

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12 December 2020

Effect of diphosphonates on the synthesis of prostaglandins in cultured calvaria cells

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12 December 2020

Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis

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12 December 2020

Distribution of 3-amino-1-hydroxypropane-1,1-diphosphonic acid in rats and effects on rat osteosarcoma

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12 December 2020

In vitro distribution of 14C-labeled ethylene-1-hydroxy-1,1-diphosphonate in normal and treated young rats. An autoradiographic and ultrastructural study

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12 December 2020

Parathyroid hormone-like changes in renal calcium and phosphate reabsorption induced by Leydig cell tumor in thyroparathyroidectomized rats

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12 December 2020

Diphosphonates inhibit bone resorption by macrophages in vitro

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12 December 2020

Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro

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12 December 2020

Diphosphonate treatment of Paget's disease of bone. A correlated metabolic, calcium kinetic and morphometric study

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12 December 2020

Treatment of bone metastases from breast cancer and myeloma with pamidronate.

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12 December 2020

Maintenance etidronate in the prevention of malignancy-associated hypercalcemia

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12 December 2020

A comparison of single and multiple intravenous infusions of 3-amino-1-hydroxypropylidene-1, 1-bisphosphonate (APD) in the treatment of hypercalcemia of malignancy

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12 December 2020

Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy

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12 December 2020

Hypercalcemia induced with an arotinoid in thyroparathyroidectomized rats. New model to study bone resorption in vivo

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12 December 2020

The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo.

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12 December 2020

Dose/response study of aminohydroxypropylidene bisphosphonate in tumor-associated hypercalcemia

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12 December 2020

Hypercalcemia in malignancies: treatment with dichloromethylene diphosphonate (Cl2MDP)

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12 December 2020

Efficacy of oral administration of etidronate disodium in maintaining normal serum calcium levels in previously hypercalcemic cancer patients

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12 December 2020

Treatment of malignant hypercalcaemia with clodronate

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12 December 2020

(Dichloromethylene)diphosphonate-induced impairment of T-lymphocyte function

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12 December 2020

Treatment of painful prostatic bone metastases with oral etidronate disodium

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12 December 2020

Re-186(Sn) HEDP for treatment of painful osseous metastases: initial clinical experience in 20 patients with hormone-resistant prostate cancer

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12 December 2020

Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo

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12 December 2020

Side-effects of pamidronate

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12 December 2020

Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat.

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12 December 2020

Inhibition by aminohydroxypropylidene bisphosphonate (AHPrBP) of 1,25(OH)2 vitamin D3-induced stimulated bone turnover in the mouse

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12 December 2020

Comparison of aminohydroxypropylidene diphosphonate, mithramycin, and corticosteroids/calcitonin in treatment of cancer-associated hypercalcaemia.

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12 December 2020

Hypercalcemia of malignancy: treatment with intravenous dichloromethylene diphosphonate

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12 December 2020

Apposition and resorption of bone during oral treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD)

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12 December 2020

The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals

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12 December 2020

Effects of disodium dichloromethylene diphosphonate on hypercalcemia produced by bone metastases

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12 December 2020

Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo.

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12 December 2020

Inorganic pyrophosphate in plasma in normal persons and in patients with hypophosphatasia, osteogenesis imperfecta, and other disorders of bone

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12 December 2020

Efficacy of amino-hydroxypropylidene bisphosphonate in hypercalcemia: observations on regulation of serum calcium

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12 December 2020

Etidronate disodium: a new therapy for hypercalcemia of malignancy. Proceedings of a symposium

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12 December 2020

Treatment of tumor hypercalcemia with clodronate. Effect on parathormone and calcitriol

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12 December 2020

The effects of diphosphonates, polyphosphates, and calcitonin on "immobilisation osteoporosis" in rats

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12 December 2020

The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised r

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12 December 2020

Etidronate disodium for treating hypercalcaemia of malignancy: a double blind, placebo-controlled study

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12 December 2020

Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow.

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12 December 2020

The use of dichloromethylene diphosphonate for the management of hypercalcaemia in multiple myeloma

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12 December 2020

The inhibition of calcium hydroxypatite crystal growth by polyphosphonates and polyphosphates

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12 December 2020

The uptake of clodronate (dichloromethylene bisphosphonate) by macrophages in vivo and in vitro

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12 December 2020

Oral versus intravenous AHPrBP (APD) in the treatment of hypercalcemia of malignancy

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12 December 2020

Prevention of ectopic bone formation by local application of ethane-1-hydroxy-1,1-diphosphonate (EHDP): an experimental study in rabbits

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12 December 2020

Effect of a single injection of two new bisphosphonates on the hypercalcemia and hypercalciuria induced by Walker carcinosarcoma 256/B in thyroparathyroidectomized rats

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12 December 2020

The subcellular distribution of [14C]dichloromethylenebisphosphonate and [14C]1-hydroxyethylidene-1,1-bisphosphonate in cultured calvaria cells

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12 December 2020

Effect of dichloromethylene diphosphonate in Paget's disease of bone and in hypercalcaemia due to primary hyperparathyroidism or malignant disease

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12 December 2020

Therapy of hypercalcemia due to parathyroid carcinoma with intravenous dichloromethylene diphosphonate

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12 December 2020

The long-term skeletal effects of EHDP in dogs

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12 December 2020

Comparison of two parenteral diphosphonates in hypercalcemia of malignancy

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12 December 2020

The hyperphosphatemic effect of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP TM ): renal handling of phosphorus and the renal response to parathyroid hormone

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12 December 2020

Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) in rats

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12 December 2020

The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution

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12 December 2020

The acute-phase response after bisphosphonate administration

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12 December 2020

Effect of dichloromethane diphosphonate on cortisol-induced bone loss in young adult rabbits

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12 December 2020

The effects of diphosphonates on the growth and glycolysis of connective-tissue cells in culture

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12 December 2020

Clodronate in hypercalcemia of malignancy

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12 December 2020

Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats

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12 December 2020

Mechanisms of calcification: role of collagen, polyphosphates, and phosphatase

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12 December 2020

Intravenous etidronate in the management of malignant hypercalcemia

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12 December 2020

Influence of diphosphonate on experimental heparin-osteopathy

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12 December 2020

Paget's disease of bone: early and late responses to three different modes of treatment with aminohydroxypropylidene bisphosphonate (APD).

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12 December 2020

Diphosphonates in Paget's disease

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12 December 2020

Short- and long-term effects of a single dose of bisphosphonates on retinoid-induced bone resorption in thyroparathyroidectomized rats

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12 December 2020

Long-term controlled trial with diphosphonate in patients with osteolytic bone metastases

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12 December 2020

A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression

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12 December 2020

Parathyroid hormone-related protein purified from a human lung cancer cell line

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12 December 2020

Clinical experience with aminohydroxypropylidene bisphosphonate (APD) in the management of cancer-associated hypercalcaemia

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12 December 2020

Effects of a new bisphosphonate (AHBuBP) on osteolysis induced by human prostate cancer cells in nude mice

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12 December 2020

Effect of etidronate disodium on the interactions between malignancy and bone

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12 December 2020

Reduction in calcium excretion in women with breast cancer and bone metastases using the oral bisphosphonate pamidronate

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12 December 2020

The effect of ethane-1-hydroxy-1, 1-diphosphonic acid (EHDP) on matrix induced ectopic bone formation

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12 December 2020

The effect of several diphosphonates on acid phosphohydrolases and other lysosomal enzymes

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12 December 2020

Inhibition by pyrophosphate and polyphosphate of aortic calcification induced by vitamin D3 in rats.

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12 December 2020

Treatment of the hypercalcaemia of malignancy with intravenous clodronate

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12 December 2020

Effects of intravenous etidronate disodium on skeletal and calcium metabolism

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12 December 2020

Dichloromethylene-diphosphonate in patients with prostatic carcinoma metastatic to the skeleton

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12 December 2020

APD in Paget's disease of bone. Role of the mononuclear phagocyte system?

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12 December 2020

Hypercalcaemia of malignancy: evidence for a nonparathyroid humoral agent with an effect on renal tubular handling of calcium

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12 December 2020

The effects of disodium etidronate on the reproductive functions and embryogeny of albino rats and New Zealand rabbits

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12 December 2020

Assessment of renal and skeletal components of hypercalcemia

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12 December 2020

Mechanism of malignant hypercalcaemia in carcinoma of the breast

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12 December 2020

The Walker 256/B carcinosarcoma in thyroparathyroidectomized rats: a model to evaluate inhibitors of bone resorption

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12 December 2020

Simple treatment of tumor-induced hypercalcemia: i.v. aminohydroxypropylidene biphosphonate

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12 December 2020

Effect of sodium etidronate in adult cats

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12 December 2020

The treatment of osteoporosis with disodium ethane-1, 1-diphosphonate

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12 December 2020

Effects of diphosphonate and x-rays on bone lesions induced in rats by prostate cancer cells

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12 December 2020

Palliation of painful bone metastases from prostate cancer using sodium etidronate: results of a randomized, prospective, double-blind, placebo-controlled study

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12 December 2020

Single dose versus daily intravenous aminohydroxypropylidene biphosphonate (APD) for the hypercalcaemia of malignancy

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12 December 2020

Dichloromethylenebisphosphonate (Cl2MBP) inhibits bone resorption through injury to osteoclasts that resorb Cl2MBP-coated bone

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12 December 2020

The short-term effects of high doses of ethylene-1-hydroxy-1, 1-diphosphonate upon early dentin formation

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12 December 2020

Treatment of hypercalcemia in osteolytic metastases with oral amino-hydroxypropylidene-diphosphonate

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12 December 2020

Structure-activity relationships of various bisphosphonates

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12 December 2020

Treatment of cancer associated hypercalcaemia with combined aminohydroxypropylidene diphosphonate and calcitonin

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12 December 2020

Effect of dichloromethylene diphosphonate (Cl2MDP) on immune function in breast cancer patients with bone metastases

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12 December 2020

Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone

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12 December 2020

Enhancement of the inhibitory action of APD on the transformation of osteoclast precursors into resorbing cells after dimethylation of the amino group

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12 December 2020

Comparison of intravenous (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate and volume repletion in tumour-induced hypercalcaemia

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12 December 2020

Pharmacokinetics of the osteotropic diphosphonate 3-amino-1-hydroxypropane-1,1-diphosphonic acid in mammals.

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12 December 2020

The tissue distribution of clodronate (dichloromethylene bisphosphonate) in mice. The effects of vehicle and the route of administration

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12 December 2020

A one year follow-up study of the distribution of 14C-clodronate in mice and rats

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12 December 2020

Influence of dichloromethylene diphosphonate (Cl2MDP) and calcitonin on bone resorption, lactate production and phosphatase and pyrophosphatase content of mouse calvaria treated with parathyroid hormone in vitro

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12 December 2020

Pharmacokinetics of disodium clodronate after daily intravenous infusions during five consecutive days

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12 December 2020

Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat

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12 December 2020

Treatment of hypercalcemia of myelomatous origin with intravenous diphosphonates

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12 December 2020

A model of localized osteolysis induced by the MBT-2 tumor in mice and its responsiveness to etidronate disodium

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12 December 2020

Interference of dichloromethane diphosphonate with parathyroid hormone effects at the bone but not at the kidney level

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12 December 2020

Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease

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12 December 2020

Results of prolonged treatment of Paget's disease of bone with disodium ethane-1-hydroxy-1, 1-diphosphonate (EHDP)

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12 December 2020

High extracellular calcium increases the production of a parathyroid hormone-like activity by cultured Leydig tumor cells associated with humoral hypercalcemia

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12 December 2020

Influence of treatment with APD-bisphosphonate on the bone lesions in the mouse 5T2 multiple myeloma

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12 December 2020

The influence of two diphosphonates on calcium metabolism in the rat

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12 December 2020

Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat

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12 December 2020

BM 21.0955, a potent new bisphosphonate to inhibit bone resorption

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12 December 2020

Response to retreatment of malignant hypercalcemia with the bisphosphonate AHPrBP (APD): respective role of kidney and bone.

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12 December 2020

Isolation from urine of pyrophosphate, a calcification inhibitor

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12 December 2020

The effect of two diphosphonates on the resorption of mouse calvaria in vitro

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12 December 2020

The control of dental calculus in experimental animals.

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12 December 2020

Long-Term Effects of Dichloromethylene Diphosphonate (Cl2 DP) on skeletal Lesions in Multiple Myeloma

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12 December 2020

Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide

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12 December 2020

Advances in the management of Paget's disease of bone

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12 December 2020

Renal secretion of diphosphonates in rats

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12 December 2020

Dichloromethylene diphosphonate (Cl2MDP) treatment of hypercalcaemia produced from bone metastases (author's transl)

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12 December 2020

Protective effects of a prophylactic treatment with the bisphosphonate 3-amino-1-hydroxypropane-1,1-bisphosphonic acid on the development of tumor osteopathies in the rat: experimental studies with the Walker carcinosarcoma 256

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12 December 2020

Treatment of painful bone lesions and hypercalcemia

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12 December 2020

Antiresorptive dose-response relationships across three generations of bisphosphonates

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12 December 2020

Effects of diphosphonate on osteoporosis induced in rats. Roentogenological, histological and biomechanical studies

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12 December 2020

Comparative effects of calcitonin and clodronate in hypercalcaemia

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12 December 2020

Reduced morbidity from skeletal metastases in breast cancer patients during long-term bisphosphonate (APD) treatment

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12 December 2020

3(Amino-1,1-hydroxypropylidene) bisphosphonate (APD) for hypercalcaemia of breast cancer

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12 December 2020

Use of Dichloromethylene Diphosphonate in Metastatic Bone Disease

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12 December 2020

Relief of metastatic bone pain with etidronate disodium

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12 December 2020

10.2165/00003495-199142060-00003

Identifiers

DOI

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Dimensions Publication ID

15 August 2017

1018474661

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