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Neural agrin: a synaptic stabiliser.

scientific article published on 25 October 2006

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17126587

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22 December 2019

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Neural agrin: a synaptic stabiliser (English)

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17126587

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22 December 2019

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17126587

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Peter G. Noakes

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17126587

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William Daniel Phillips

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Peter G Noakes

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25 October 2006

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International Journal of Biochemistry & Cell Biology

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17126587

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39

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5

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863-867

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22 December 2019

cites work

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1 reference

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The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans

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Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse

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Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis

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The laminin-binding domain of agrin is structurally related to N-TIMP-1

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Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1

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Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors.

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Agrin regulates rapsyn interaction with surface acetylcholine receptors, and this underlies cytoskeletal anchoring and clustering

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Structural domains of agrin required for clustering of nicotinic acetylcholine receptors.

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Defective neuromuscular synaptogenesis in agrin-deficient mutant mice

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Identification of agrin, a synaptic organizing protein from Torpedo electric organ

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Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction

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Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering

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Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction

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MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation

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Lipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clustering.

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(Q36663472)

Neural agrin: a synaptic stabiliser.

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