(Q36292892)

13 August 2017

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title

Helix-loop-helix proteins and lymphocyte development (English)

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13 August 2017

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1

Cornelis Murre

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13 August 2017

language of work or name

English

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publication date

1 November 2005

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13 August 2017

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13 August 2017

volume

6

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13 August 2017

issue

11

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13 August 2017

page(s)

1079-1086

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New insights into E-protein function in lymphocyte development

13 August 2017

cites work

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Multitasking of helix-loop-helix proteins in lymphopoiesis

21 January 2018

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E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins

21 January 2018

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Phosphorylation of E47 as a potential determinant of B-cell-specific activity

21 January 2018

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B-cell-specific DNA binding by an E47 homodimer

21 January 2018

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A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines

21 January 2018

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A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

21 January 2018

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The E2A gene product contains two separable and functionally distinct transcription activation domains

21 January 2018

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A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells

21 January 2018

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The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells

21 January 2018

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An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers

21 January 2018

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Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms

21 January 2018

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T-lineage specification and commitment: a gene regulation perspective

21 January 2018

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The protein Id: a negative regulator of helix-loop-helix DNA binding proteins

21 January 2018

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High Incidence of T-Cell Tumors in E2A-Null Mice and E2A/Id1 Double-Knockout Mice

21 January 2018

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Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3.

21 January 2018

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Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.

21 January 2018

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Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene

21 January 2018

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Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent

21 January 2018

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A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex

21 January 2018

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p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene

21 January 2018

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Regulation of E2A activities by histone acetyltransferases in B lymphocyte development

21 January 2018

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E protein silencing by the leukemogenic AML1-ETO fusion protein

21 January 2018

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BIOLOGY OF HEMATOPOIETIC STEM CELLS AND PROGENITORS: Implications for Clinical Application

21 January 2018

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

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Notch1 expression in early lymphopoiesis influences B versus T lineage determination

21 January 2018

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Molecular genetics of T cell development

21 January 2018

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

21 January 2018

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The helix-loop-helix gene E2A is required for B cell formation

21 January 2018

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Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

21 January 2018

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E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

21 January 2018

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Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB

21 January 2018

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Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2.

21 January 2018

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Regulation of E2A gene expression in B-lymphocyte development

21 January 2018

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Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

21 January 2018

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BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

21 January 2018

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Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow

21 January 2018

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Transcriptional control of early B cell development

21 January 2018

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Both E12 and E47 allow commitment to the B cell lineage

21 January 2018

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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.

21 January 2018

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Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression

21 January 2018

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Failure of B-cell differentiation in mice lacking the transcription factor EBF.

21 January 2018

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Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments

21 January 2018

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Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A

21 January 2018

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Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.

21 January 2018

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Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.

21 January 2018

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Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

21 January 2018

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Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription.

21 January 2018

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Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A

21 January 2018

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Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes

21 January 2018

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Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene

21 January 2018

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Gradient of E2A activity in B-cell development

21 January 2018

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A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

21 January 2018

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E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells

21 January 2018

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Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangement

21 January 2018

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Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells

21 January 2018

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Positive and negative regulation of V(D)J recombination by the E2A proteins

21 January 2018

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A stepwise epigenetic process controls immunoglobulin allelic exclusion

21 January 2018

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Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response

21 January 2018

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Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

21 January 2018

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E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination

21 January 2018

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E-proteins directly regulate expression of activation-induced deaminase in mature B cells

21 January 2018

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Localization of E2A mRNA expression in developing and adult rat tissues

21 January 2018

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The balance between Pax5 and Id2 activities is the key to AID gene expression

21 January 2018

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Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2

21 January 2018

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Transcriptional profiling identifies Id2 function in dendritic cell development

21 January 2018

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Early thymocyte development is regulated by modulation of E2A protein activity

21 January 2018

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Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line

21 January 2018

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E2A proteins enforce a proliferation checkpoint in developing thymocytes

21 January 2018

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Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47

21 January 2018

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Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

21 January 2018

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Thymocyte development in early growth response gene 1-deficient mice

21 January 2018

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Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta

21 January 2018

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Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells

21 January 2018

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Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover

21 January 2018

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A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome.

21 January 2018

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Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling

21 January 2018

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Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity

21 January 2018

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Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

21 January 2018

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Notch inhibition of E47 supports the existence of a novel signaling pathway

21 January 2018

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Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities

21 January 2018

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Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination

21 January 2018

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Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas

21 January 2018

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IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors

21 January 2018

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Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice

21 January 2018

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Promotion of cell cycle progression by basic helix-loop-helix E2A

21 January 2018

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Requirement for cyclin D3 in lymphocyte development and T cell leukemias

21 January 2018

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Overexpression of the Helix-Loop-Helix protein Id2 blocks T cell development at multiple stages.

21 January 2018

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Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells

21 January 2018

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Transcription factors in hematopoiesis

21 January 2018

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TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

21 January 2018

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The role of E2A-PBX1 in leukemogenesis

21 January 2018

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The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes

21 January 2018

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The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.

21 January 2018

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Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma

21 January 2018

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Id family of helix-loop-helix proteins in cancer

21 January 2018

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Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

21 January 2018

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Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection

21 January 2018

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Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers

21 January 2018

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7 January 2021

Thymopoiesis independent of common lymphoid progenitors

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7 January 2021

Circulating hematopoietic progenitors with T lineage potential

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7 January 2021

Constitutive expression of the Id1 gene impairs mouse B cell development

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7 January 2021

The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription

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7 January 2021

Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching

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7 January 2021

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression

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7 January 2021

Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice

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7 January 2021

Identifiers

DOI

10.1038/NI1260

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Dimensions Publication ID

13 August 2017

1011080576

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