(Q36079218)

12 August 2017

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title

Kinomics: methods for deciphering the kinome (English)

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12 August 2017

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Sam A Johnson

1

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12 August 2017

Tony Hunter

series ordinal

2

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12 August 2017

publication date

1 January 2005

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12 August 2017

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12 August 2017

volume

2

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12 August 2017

issue

1

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12 August 2017

page(s)

17-25

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Signaling--2000 and beyond

12 August 2017

cites work

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7 January 2021

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta

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7 January 2021

A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate

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7 January 2021

Selection of v-abl tyrosine kinase substrate sequences from randomized peptide and cellular proteomic libraries using mRNA display

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7 January 2021

Analysis of yeast protein kinases using protein chips.

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7 January 2021

Peptide arrays: from macro to micro

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7 January 2021

Target specificity analysis of the Abl kinase using peptide microarray data

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7 January 2021

Global analysis of protein activities using proteome chips

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7 January 2021

Towards quantitative assays with peptide chips: a surface engineering approach

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7 January 2021

Preparing protein microarrays by soft-landing of mass-selected ions

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7 January 2021

Killing the messenger: short RNAs that silence gene expression

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7 January 2021

Activation of the interferon system by short-interfering RNAs

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7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

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7 January 2021

Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.

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7 January 2021

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

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7 January 2021

Design of allele-specific inhibitors to probe protein kinase signaling

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7 January 2021

Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

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7 January 2021

Functional organization of the yeast proteome by systematic analysis of protein complexes

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7 January 2021

Ser-3 Is Important for Regulating Mos Interaction with and Stimulation of Mitogen-Activated Protein Kinase Kinase

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7 January 2021

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

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7 January 2021

A role for Plk1 phosphorylation of NudC in cytokinesis

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7 January 2021

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

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7 January 2021

A rapid method for determining protein kinase phosphorylation specificity

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7 January 2021

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

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7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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7 January 2021

A mechanism-based cross-linker for the identification of kinase-substrate pairs

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7 January 2021

Specific dephosphorylation of phosphoproteins by protein-serine and -tyrosine kinases

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7 January 2021

Single-cell kinase assays: opening a window onto cell behavior

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7 January 2021

Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry

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7 January 2021

Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane

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7 January 2021

Green Fluorescent Protein (GFP)-tagged Cysteine-rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells

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7 January 2021

Control of astrocyte Ca(2+) oscillations and waves by oscillating translocation and activation of protein kinase C.

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7 January 2021

Solvent-sensitive dyes to report protein conformational changes in living cells

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7 January 2021

Visualization of the spatial and temporal dynamics of intracellular signaling

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7 January 2021

Fluorescence ratio imaging of cyclic AMP in single cells

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7 January 2021

In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation

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7 January 2021

Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse

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7 January 2021

Molecular imaging in living subjects: seeing fundamental biological processes in a new light

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7 January 2021

The ABC's (and XYZ's) of peptide sequencing

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7 January 2021

Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome

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7 January 2021

Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry

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7 January 2021

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry

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7 January 2021

Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway

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7 January 2021

Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome

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7 January 2021

Large-scale characterization of HeLa cell nuclear phosphoproteins

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7 January 2021

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

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7 January 2021

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics

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7 January 2021

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

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7 January 2021

Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

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7 January 2021

Phosphoserine/threonine-binding domains

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7 January 2021

A repertoire library that allows the selection of synthetic SH2s with altered binding specificities

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7 January 2021

Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

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7 January 2021

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

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7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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7 January 2021

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

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7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

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7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

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7 January 2021

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

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7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

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7 January 2021

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

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7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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7 January 2021

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

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7 January 2021

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

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7 January 2021

Identifiers

DOI

10.1038/NMETH731

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12 August 2017

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