(Q35925845)

11 August 2017

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title

The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion (English)

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11 August 2017

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Timothy A Springer

1

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11 August 2017

Jia-Huai Wang

series ordinal

2

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11 August 2017

publication date

1 January 2004

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Advances in Protein Chemistry

11 August 2017

published in

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11 August 2017

volume

68

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11 August 2017

page(s)

29-63

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Does the integrin alphaA domain act as a ligand for its betaA domain?

11 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Antibody to integrin alpha 6 subunit specifically inhibits cell-binding to laminin fragment 8

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

1 reference

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7 January 2021

Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

C-cadherin ectodomain structure and implications for cell adhesion mechanisms

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7 January 2021

Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

γ-γ Cross-linking sites in human and bovine fibrin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

The laminin alpha2-chain short arm mediates cell adhesion through both the alpha1beta1 and alpha2beta1 integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Form and function: the laminin family of heterotrimers

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

1 reference

7 January 2021

Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha 6beta 4

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Three-dimensional structure of the platelet integrin recognition segment of the fibrinogen gamma chain obtained by carrier protein-driven crystallization

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Structural basis of collagen recognition by integrin alpha2beta1

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Collagen: molecular diversity in the body's protein scaffold

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Structural determinants of integrin recognition by talin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Localization of a major nidogen-binding site to domain III of laminin B2 chain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

The role of alpha and beta chains in ligand recognition by beta 7 integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

1 reference

7 January 2021

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Integrins: versatility, modulation, and signaling in cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

The evolution of cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

The collagen-binding A-domains of integrins alpha(1)beta(1) and alpha(2)beta(1) recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Structure of a Fibronectin Type III Domain from Tenascin Phased by MAD Analysis of the Selenomethionyl Protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

The integrin alpha 6 beta 4 is a laminin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

High affinity ligand binding by integrins does not involve head separation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

LG/LNS domains: multiple functions -- one business end?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

New perspectives in cell adhesion: RGD and integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Fibronectin: from gene to protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Structural biology of cadherins in the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Crystal structure of a heparin- and integrin-binding segment of human fibronectin.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Therapeutic antagonists and conformational regulation of integrin function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Conformational regulation of integrin structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin gamma1 chain harboring the nidogen binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Changing Ligand Specificities of αvβ1 and αvβ3 Integrins by Swapping a Short Diverse Sequence of the β Subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Integrin activation and structural rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Structure of integrin alpha5beta1 in complex with fibronectin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Cadherins: a molecular family important in selective cell-cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

E-cadherin is a ligand for integrin α2β1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Solution structure of a pair of fibronectin type 1 modules with fibrin binding activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Crystal structure of native chicken fibrinogen at 2.7 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2968002-8

7 January 2021

10.1016/S0065-3233(04)68002-8

Identifiers

DOI

1 reference

11 August 2017

1 reference