(Q35910747)

11 August 2017

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title

Role of DNA mismatch repair in apoptotic responses to therapeutic agents (English)

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11 August 2017

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Mark Meyers

1

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11 August 2017

Arlene Hwang

series ordinal

2

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11 August 2017

Mark W Wagner

series ordinal

3

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11 August 2017

David A Boothman

series ordinal

4

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11 August 2017

publication date

1 January 2004

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Environmental and Molecular Mutagenesis

11 August 2017

published in

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11 August 2017

volume

44

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11 August 2017

issue

4

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11 August 2017

page(s)

249-264

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Topoisomerase I poisons and suppressors as anticancer drugs

11 August 2017

cites work

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Apoptosis genes and resistance to cancer therapy: what does the experimental and clinical data tell us?

21 January 2018

1 reference

Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate

21 January 2018

1 reference

μ-Calpain Activation in β-Lapachone-Mediated Apoptosis

21 January 2018

1 reference

Apoptotic Response to 5-Fluorouracil Treatment Is Mediated by Reduced Polyamines, Non-Autocrine Fas Ligand and Induced Tumor Necrosis Factor Receptor 2

21 January 2018

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DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

21 January 2018

1 reference

7 January 2021

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

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7 January 2021

Human ICE/CED-3 protease nomenclature

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7 January 2021

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

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7 January 2021

Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells.

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7 January 2021

Mismatch repair, G(2)/M cell cycle arrest and lethality after DNA damage.

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7 January 2021

Mismatch repair in correction of replication errors and processing of DNA damage

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7 January 2021

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

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7 January 2021

Survey of human and rat microsatellites.

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7 January 2021

Functional interactions and signaling properties of mammalian DNA mismatch repair proteins

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7 January 2021

p53-dependent pathways of apoptosis

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7 January 2021

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

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7 January 2021

Induction of mutations in mouse FM3A cells by treatment with riboflavin plus visible light and its possible relation with formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA.

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7 January 2021

Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents

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7 January 2021

X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

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7 January 2021

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

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7 January 2021

Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: the role of DNA base damage

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7 January 2021

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

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7 January 2021

Mammalian DNA mismatch repair

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7 January 2021

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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7 January 2021

Mismatch repair proficiency and in vitro response to 5-fluorouracil

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7 January 2021

Is mismatch repair really required for ionizing radiation-induced DNA damage signaling?

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7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

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7 January 2021

Msh2 deficiency does not contribute to cisplatin resistance in mouse embryonic stem cells

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7 January 2021

The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool

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7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

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7 January 2021

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

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7 January 2021

Repair of oxidative damage to DNA: enzymology and biology

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7 January 2021

Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation

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7 January 2021

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

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7 January 2021

hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage

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7 January 2021

Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related

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7 January 2021

Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes.

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7 January 2021

Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II)

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7 January 2021

The role of p53 in chemosensitivity and radiosensitivity.

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7 January 2021

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

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7 January 2021

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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7 January 2021

Mismatch repair, molecular switches, and signal transduction

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7 January 2021

Signaling mismatch repair in cancer

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7 January 2021

Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia.

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7 January 2021

Expression of Wild-type p53 Is Required for Efficient Global Genomic Nucleotide Excision Repair in UV-irradiated Human Fibroblasts

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7 January 2021

The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase

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7 January 2021

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

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7 January 2021

Clinical relevance of MGMT in the treatment of cancer

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7 January 2021

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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7 January 2021

Apoptotic pathways: paper wraps stone blunts scissors

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7 January 2021

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

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7 January 2021

BCL-2 family members and the mitochondria in apoptosis

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7 January 2021

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

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7 January 2021

The biochemistry of apoptosis

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7 January 2021

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

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7 January 2021

Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine.

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7 January 2021

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

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7 January 2021

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

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7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

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7 January 2021

Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

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7 January 2021

Death and anti-death: tumour resistance to apoptosis

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7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

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7 January 2021

Molecular mechanisms involved in cisplatin cytotoxicity.

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7 January 2021

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex−, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

1 reference

7 January 2021

BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis

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7 January 2021

DNA damage tolerance, mismatch repair and genome instability

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7 January 2021

Mechanisms of tolerance to DNA damaging therapeutic drugs

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7 January 2021

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

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7 January 2021

DNA damage and cell cycle checkpoints

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7 January 2021

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

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7 January 2021

p53: puzzle and paradigm

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7 January 2021

Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

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7 January 2021

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

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7 January 2021

CD95(APO-1/Fas)-mediated apoptosis: live and let die

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7 January 2021

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

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7 January 2021

Apoptosis-an introduction

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7 January 2021

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

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7 January 2021

p53, the cellular gatekeeper for growth and division

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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7 January 2021

p53 interacts with the DNA mismatch repair system to modulate the cytotoxicity and mutagenicity of hydrogen peroxide

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7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update

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7 January 2021

Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status

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7 January 2021

Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine

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7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021

A novel receptor for Apo2L/TRAIL contains a truncated death domain

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7 January 2021

Apoptosis in development

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7 January 2021

The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin

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7 January 2021

A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage.

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7 January 2021

Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

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7 January 2021

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

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7 January 2021

p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

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7 January 2021

An induced proximity model for caspase-8 activation.

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7 January 2021

Apoptotic DNA fragmentation

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7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

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7 January 2021

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

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7 January 2021

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

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7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

1 reference

7 January 2021

Combined mismatch and nucleotide excision repair defects in a human cell line: mismatch repair processes methylation but not UV- or ionizing radiation-induced DNA damage.

1 reference

7 January 2021

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

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7 January 2021

The receptor for the cytotoxic ligand TRAIL

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7 January 2021

Mutation of a mutL homolog in hereditary colon cancer

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7 January 2021

Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

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7 January 2021

The significance of DNA and protein adducts in human biomonitoring studies

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7 January 2021

A model for p53-induced apoptosis

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7 January 2021

Effect of radiation quality on lesion complexity in cellular DNA

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7 January 2021

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

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7 January 2021

Lamin proteolysis facilitates nuclear events during apoptosis

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7 January 2021

"Recruitment signals" from apoptotic cells: invitation to a quiet meal

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7 January 2021

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

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7 January 2021

DNA base changes induced following in vivo exposure of unadapted, adapted or ada- Escherichia coli to N-methyl-N'-nitro-N-nitrosoguanidine

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7 January 2021

Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

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7 January 2021

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

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7 January 2021

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

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7 January 2021

Apoptosome: the seven-spoked death machine

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7 January 2021

Regulation of death receptor-mediated apoptosis pathways

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7 January 2021

DNA mismatch repair: molecular mechanisms and biological function

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7 January 2021

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

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7 January 2021

Apoptosome: the cellular engine for the activation of caspase-9.

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7 January 2021

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

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7 January 2021

p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes

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7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

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7 January 2021

A role for mismatch repair in control of DNA ploidy following DNA damage

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7 January 2021

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

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7 January 2021

Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53.

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7 January 2021

Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine.

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7 January 2021

Calcium is a key signaling molecule in beta-lapachone-mediated cell death

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7 January 2021

Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis

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7 January 2021

Radiation-induced DNA damage and its repair.

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7 January 2021

Functional analysis of the mismatch repair system in bladder cancer

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7 January 2021

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

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7 January 2021

In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: correlations with senile plaques and disease progression

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7 January 2021

Live or let die: the cell's response to p53

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7 January 2021

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

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7 January 2021

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7 January 2021

BID: a novel BH3 domain-only death agonist

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7 January 2021

The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review

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7 January 2021

A change in microsatellite instability caused by cisplatin-based chemotherapy of ovarian cancer

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7 January 2021

And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis

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7 January 2021

Cytotoxic mechanism of 6-thioguanine: hMutSalpha, the human mismatch binding heterodimer, binds to DNA containing S6-methylthioguanine

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7 January 2021

Renewing the debate over the p53 apoptotic response

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.

1 reference

7 January 2021

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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7 January 2021

Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest

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7 January 2021

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

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7 January 2021

Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins.

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7 January 2021

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

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7 January 2021

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

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7 January 2021

Identifiers

DOI

10.1002/EM.20056

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11 August 2017

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