(Q35903675)

English

Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice

scientific article published in January 1997

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scholarly article

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Europe PubMed Central

PMC publication ID

11 August 2017

Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

author name string

Q Liu

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

J Bungert

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

J D Engel

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

language of work or name

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publication date

1 January 1997

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PMC publication ID

11 August 2017

94

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

169-174

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Distinct negative regulation of the human embryonic globin genes zeta and epsilon.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Protein-DNA interactions in the epsilon-globin gene silencer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Phylogenetic footprinting reveals unexpected complexity in trans factor binding upstream from the epsilon-globin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Developmental regulation of human gamma-globin genes in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Developmental regulation of the human embryonic beta-like globin gene is mediated by synergistic interactions among multiple tissue- and stage-specific elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

A method for the generation of YAC transgenic mice by pronuclear microinjection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Allelic inactivation regulates olfactory receptor gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

GATA1 and YY1 are developmental repressors of the human epsilon-globin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

An enhancer deletion affects both H19 and Igf2 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Disruption of imprinting caused by deletion of the H19 gene region in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

The "beta-like-globin" gene domain in human erythroid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

An enhancer element lies 3' to the human A gamma globin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Developmental regulation of beta-globin gene switching.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Developmentally regulated and erythroid-specific expression of the human embryonic beta-globin gene in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Transcriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Physical mapping of yeast artificial chromosomes containing sequences from the human beta-globin gene region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Importance of globin gene order for correct developmental expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Human gamma- to beta-globin gene switching in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

The epsilon-globin gene silencer. Characterization by in vitro transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Individual stage selector element mutations lead to reciprocal changes in beta- vs. epsilon-globin gene transcription: genetic confirmation of promoter competition during globin gene switching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Binding of erythroid and non-erythroid nuclear proteins to the silencer of the human epsilon-globin-encoding gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

The 1991 Albert Lasker Medical Awards. Clusters of master control genes regulate the development of higher organisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

11 July 2018

Transcription complex stability and chromatin dynamics in vivo

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.1.169

21 January 2018

Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.1.169

21 January 2018

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.1.169

21 January 2018

Distinct negative regulatory mechanisms involved in the repression of human embryonic epsilon- and fetal G gamma-globin genes in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19271

24 September 2018

Human γ-globin genes silenced independently of other genes in the β-globin locus

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.1.169

21 January 2018

Human hemoglobin switching

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.1.169

21 January 2018

Identifiers

10.1073/PNAS.94.1.169

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1997PNAS...94..169L

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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