(Q35840040)

10 August 2017

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title

Lewy-body formation is an aggresome-related process: a hypothesis (English)

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10 August 2017

author

Charles Warren Olanow

series ordinal

1

object named as

C Warren Olanow

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10 August 2017

Daniel P Perl

2

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10 August 2017

George N DeMartino

series ordinal

3

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10 August 2017

Kevin St P McNaught

series ordinal

4

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10 August 2017

publication date

1 August 2004

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10 August 2017

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10 August 2017

volume

3

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10 August 2017

issue

8

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10 August 2017

page(s)

496-503

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An algorithm (decision tree) for the management of Parkinson's disease (2001): treatment guidelines

10 August 2017

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The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease

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7 January 2021

Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson's disease

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7 January 2021

Aggresomes, inclusion bodies and protein aggregation

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7 January 2021

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7 January 2021

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin

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7 January 2021

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

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7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

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7 January 2021

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

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7 January 2021

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

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7 January 2021

Contribution of somal Lewy bodies to neuronal death

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7 January 2021

Stability of cell size and nucleolar size in Lewy body containing neurons of substantia nigra in Parkinson's disease

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7 January 2021

Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

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7 January 2021

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

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7 January 2021

Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease

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7 January 2021

α-Synuclein in Lewy bodies

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7 January 2021

Synphilin-1 is present in Lewy bodies in Parkinson's disease

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7 January 2021

TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease

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7 January 2021

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

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7 January 2021

Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.

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7 January 2021

Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

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7 January 2021

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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7 January 2021

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

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7 January 2021

Protein nitration in Parkinson's disease

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7 January 2021

alpha-Synuclein is phosphorylated in synucleinopathy lesions

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7 January 2021

In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies

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7 January 2021

γ-Tubulin is a highly conserved component of the centrosome

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7 January 2021

Pericentrin, a highly conserved centrosome protein involved in microtubule organization

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7 January 2021

Activity and regulation of the centrosome-associated proteasome

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7 January 2021

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

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7 January 2021

Aggresomes: a cellular response to misfolded proteins

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7 January 2021

Cytoplasmic dynein/dynactin mediates the assembly of aggresomes

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7 January 2021

Dynamic association of proteasomal machinery with the centrosome

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7 January 2021

Hassles with taking out the garbage: aggravating aggresomes.

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7 January 2021

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells

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7 January 2021

Parkin accumulation in aggresomes due to proteasome impairment

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7 January 2021

Aggresome formation in liver cells in response to different toxic mechanisms: role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin

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7 January 2021

Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation

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7 January 2021

Occurrence of glutamate receptor subunit 1-containing aggresome-like structures during normal development of rat spinal cord interneurons

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7 January 2021

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7 January 2021

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

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7 January 2021

An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism

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7 January 2021

Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1.

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7 January 2021

Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases

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7 January 2021

Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination

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7 January 2021

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

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7 January 2021

Axonal transport of synucleins is mediated by all rate components

1 reference

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7 January 2021

Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Altered proteasomal function in sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

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7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

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7 January 2021

Numerous and widespread alpha-synuclein-negative Lewy bodies in an asymptomatic patient

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7 January 2021

Lewy body-free nigral degeneration--a case report

1 reference

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7 January 2021

Restricted occurrence of Lewy bodies in the dorsal vagal nucleus in a patient with late-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Parkin and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

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7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Lewy bodies and parkinsonism in families with parkin mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Emerging role for autophagy in the removal of aggresomes in Schwann cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using alpha-synuclein-immunohistochemistry

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900827-0

7 January 2021

10.1016/S1474-4422(04)00827-0

Identifiers

DOI

1 reference

10 August 2017

1 reference