(Q35805053)

10 August 2017

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title

Site-specific DNA damage recognition by enzyme-induced base flipping (English)

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10 August 2017

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James T Stivers

1

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10 August 2017

publication date

1 January 2004

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Progress in Molecular Biology and Translational Science

10 August 2017

published in

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10 August 2017

volume

77

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10 August 2017

page(s)

37-65

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The base excision repair pathway

10 August 2017

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The abasic site as a challenge to DNA polymerase. A nuclear magnetic resonance study of G, C and T opposite a model abasic site

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A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

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HhaI methyltransferase flips its target base out of the DNA helix

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Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

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7 January 2021

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

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7 January 2021

Structural basis for the excision repair of alkylation-damaged DNA

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Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision

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7 January 2021

Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG

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7 January 2021

DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA

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Structural studies of human alkyladenine glycosylase and E. coli 3-methyladenine glycosylase

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7 January 2021

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

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7 January 2021

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

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7 January 2021

Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA

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7 January 2021

A mechanistic perspective on the chemistry of DNA repair glycosylases

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7 January 2021

Acidic hydrolysis of deoxycytidine and deoxyuridine derivatives. The general mechanism of deoxyribonucleoside hydrolysis

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7 January 2021

Kinetics and mechanism of the acid-catalyzed hydrolysis of some purine nucleosides

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7 January 2021

A single mode of DNA base-pair opening drives imino proton exchange

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7 January 2021

Studies of base pair kinetics by NMR measurement of proton exchange

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7 January 2021

Free energy and structural pathways of base flipping in a DNA GCGC containing sequence.

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7 January 2021

High base pair opening rates in tracts of GC base pairs

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7 January 2021

Proton exchange and base-pair opening kinetics in 5'-d(CGCGAATTCGCG)-3' and related dodecamers

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7 January 2021

Kinetics and energetics of base-pair opening in 5'-d(CGCGAATTCGCG)-3' and a substituted dodecamer containing G.T mismatches

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7 January 2021

Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylase

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7 January 2021

Base-flipping mutations of uracil DNA glycosylase: substrate rescue using a pyrene nucleotide wedge

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7 January 2021

Mutational analysis of the base-flipping mechanism of uracil DNA glycosylase

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7 January 2021

Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase.

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7 January 2021

Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: structural basis for damaged DNA recognition

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7 January 2021

2-Aminopurine fluorescence studies of base stacking interactions at abasic sites in DNA: metal-ion and base sequence effects

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7 January 2021

The Role of Base Flipping in Damage Recognition and Catalysis by T4 Endonuclease V

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7 January 2021

Base pair opening dynamics of a 2-aminopurine substituted Eco RI restriction sequence and its unsubstituted counterpart in oligonucleotides

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7 January 2021

Pre-steady-state kinetic analysis of sequence-dependent nucleotide excision by the 3'-exonuclease activity of bacteriophage T4 DNA polymerase

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7 January 2021

Melting and premelting transitions of an oligomer measured by DNA base fluorescence and absorption

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7 January 2021

Probing structure and dynamics of DNA with 2-aminopurine: effects of local environment on fluorescence

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7 January 2021

Conformation and dynamics of abasic sites in DNA investigated by time-resolved fluorescence of 2-aminopurine

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7 January 2021

Direct visualization of a DNA glycosylase searching for damage

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7 January 2021

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

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7 January 2021

Energetic coupling between DNA bending and base pair opening

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7 January 2021

Role of base flipping in specific recognition of damaged DNA by repair enzymes.

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7 January 2021

Role of DNA flexibility in sequence-dependent activity of uracil DNA glycosylase

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7 January 2021

How do DNA repair proteins locate damaged bases in the genome?

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7 January 2021

Release of normal bases from intact DNA by a native DNA repair enzyme

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7 January 2021

Effects of mutations at tyrosine 66 and asparagine 123 in the active site pocket of Escherichia coli uracil DNA glycosylase on uracil excision from synthetic DNA oligomers: evidence for the occurrence of long-range interactions between the enzyme an

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7 January 2021

Escherichia coli uracil DNA glycosylase: NMR characterization of the short hydrogen bond from His187 to uracil O2.

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7 January 2021

Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase

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7 January 2021

Processive action of T4 endonuclease V on ultraviolet-irradiated DNA

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7 January 2021

Escherichia coli MutY and Fpg utilize a processive mechanism for target location

1 reference

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7 January 2021

Processivity of Escherichia coli and rat liver mitochondrial uracil-DNA glycosylase is affected by NaCl concentration

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7 January 2021

One- and three-dimensional pathways for proteins to reach specific DNA sites

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

Protein motion from non-specific to specific DNA by three-dimensional routes aided by supercoiling

1 reference

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7 January 2021

Turning On uracil-DNA glycosylase using a pyrene nucleotide switch

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7 January 2021

The role of leucine 191 of Escherichia coli uracil DNA glycosylase in the formation of a highly stable complex with the substrate mimic, ugi, and in uracil excision from the synthetic substrates

1 reference

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7 January 2021

Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase.

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7 January 2021

Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187

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7 January 2021

The initiation of DNA base excision repair of dipyrimidine photoproducts

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7 January 2021

Potential double-flipping mechanism by E. coli MutY.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair

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7 January 2021

MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily

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7 January 2021

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7 January 2021

The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase

1 reference

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7 January 2021

Rational Engineering of a DNA Glycosylase Specific for an Unnatural Cytosine:Pyrene Base Pair

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7 January 2021

Difluorotoluene, a Nonpolar Isostere for Thymine, Codes Specifically and Efficiently for Adenine in DNA Replication

1 reference

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7 January 2021

Structure and Base Pairing Properties of a Replicable Nonpolar Isostere for Deoxyadenosine

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7 January 2021

Synthetically modified DNAs as substrates for polymerases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

Specificity of damage recognition and catalysis of DNA repair

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https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

Covalent trapping of protein-DNA complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

Decreased imino proton exchange and base-pair opening in the IHF-DNA complex measured by NMR.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

Probing molecular motion by NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

3-methyladenine DNA glycosylases: structure, function, and biological importance

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

Base excision and DNA binding activities of human alkyladenine DNA glycosylase are sensitive to the base paired with a lesion

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

Targeted base stacking disruption by the EcoRI DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2804%2977002-6

7 January 2021

10.1016/S0079-6603(04)77002-6

Identifiers

DOI

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