(Q35112198)

6 August 2017

1 reference

title

Amyloid, presenilins, and Alzheimer's disease (English)

1 reference

6 August 2017

Amyloid, Presenilins, and Alzheimer’s Disease (English)

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

26 December 2023

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12708616

26 December 2023

author name string

Geert Van Gassen

1

1 reference

6 August 2017

Wim Annaert

2

1 reference

6 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12708616

26 December 2023

publication date

1 April 2003

1 reference

full work available at URL

6 August 2017

http://journals.sagepub.com/doi/pdf/10.1177/1073858403252227

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

26 December 2023

1 reference

6 August 2017

volume

9

1 reference

6 August 2017

issue

2

1 reference

6 August 2017

page(s)

117-126

1 reference

Presenilins: molecular switches between proteolysis and signal transduction

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

A cell biological perspective on Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Presenilin-dependent gamma-secretase activity modulates thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Effects of PS1 deficiency on membrane protein trafficking in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Identification of a novel family of presenilin homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Alzheimer's disease and Abeta toxicity: from top to bottom

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403252227

Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.

21 January 2018

1

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

26 December 2023

20

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

Protein topology of presenilin 1

26 December 2023

24

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

Gamma -secretase inhibitors repress thymocyte development

26 December 2023

36

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

26 December 2023

39

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

Membrane topology of the C. elegans SEL-12 presenilin

26 December 2023

58

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure

26 December 2023

65

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

26 December 2023

103

1 reference

https://api.crossref.org/works/10.1177/1073858403252227

26 December 2023

Identifiers

1 reference

6 August 2017

1 reference