(Q35092535)

6 August 2017

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title

Regulatory T cells in transplantation tolerance. (English)

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6 August 2017

2

Shimon Sakaguchi

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6 August 2017

Kathryn J Wood

1

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6 August 2017

publication date

1 March 2003

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Nature Reviews Immunology

6 August 2017

published in

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6 August 2017

volume

3

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6 August 2017

issue

3

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6 August 2017

page(s)

199-210

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Regulatory T cells under scrutiny

6 August 2017

cites work

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The role of peripheral T-cell deletion in transplantation tolerance

31 March 2020

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Alloantigen-induced specific immunological unresponsiveness

31 March 2020

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Suppressor T cells in mice made unresponsive to skin allografts

31 March 2020

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Suppressor T cells in allogeneic models.

31 March 2020

1 reference

Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells

31 March 2020

1 reference

Oral exposure to alloantigen generates intragraft CD8+ regulatory cells

31 March 2020

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Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

31 March 2020

1 reference

Unique patterns of surface receptors, cytokine secretion, and immune functions distinguish T cells in the bone marrow from those in the periphery: impact on allogeneic bone marrow transplantation

31 March 2020

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Requirement for natural killer T (NKT) cells in the induction of allograft tolerance

31 March 2020

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CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade

31 March 2020

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Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation

31 March 2020

1 reference

CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease

31 March 2020

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The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor

31 March 2020

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Certified professionals: CD4(+)CD25(+) suppressor T cells

31 March 2020

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Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action

31 March 2020

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IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

31 March 2020

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CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses

31 March 2020

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Tracking the immunoregulatory mechanisms active during allograft tolerance

31 March 2020

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Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance

31 March 2020

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CD4+CD25high regulatory cells in human peripheral blood

31 March 2020

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Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

31 March 2020

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Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

31 March 2020

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Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

31 March 2020

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Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro

31 March 2020

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Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population

31 March 2020

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Immune receptors: targets for therapy of leukemia/lymphoma, autoimmune diseases and for the prevention of allograft rejection

31 March 2020

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Interleukin-2 receptor monoclonal antibodies in renal transplantation: current use and emerging regimens.

31 March 2020

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Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

31 March 2020

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CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations.

31 March 2020

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Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

31 March 2020

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Indirect presentation of MHC antigens in transplantation

31 March 2020

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Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells

31 March 2020

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The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice

31 March 2020

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Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade

31 March 2020

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Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine

31 March 2020

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Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat

31 March 2020

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Nondepleting anti-CD4 monoclonal antibody enhances the ability of oral alloantigen delivery to induce indefinite survival of cardiac allografts: oral tolerance to alloantigen

31 March 2020

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Effect of one-HLA-DR-antigen-matched and completely HLA-DR-mismatched blood transfusions on survival of heart and kidney allografts

31 March 2020

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Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

31 March 2020

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Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection

31 March 2020

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CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection

31 March 2020

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CD8+ T cells contribute to the development of transplant arteriosclerosis despite CD154 blockade

31 March 2020

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Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy

31 March 2020

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Dominant transplantation tolerance impairs CD8+ T cell function but not expansion

31 March 2020

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Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells

31 March 2020

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CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

31 March 2020

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"Infectious" transplantation tolerance.

31 March 2020

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Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells

31 March 2020

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Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected].

31 March 2020

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Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes.

31 March 2020

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Recipient cells expressing single donor MHC locus products can substitute for donor-specific transfusion in the induction of transplantation tolerance when pretreatment is combined with anti-Cd4 monoclonal antibody. Evidence for a vital role of Cd4+

31 March 2020

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Pretransplant administration of a single donor class I major histocompatibility complex molecule is sufficient for the indefinite survival of fully allogeneic cardiac allografts: evidence for linked epitope suppression

31 March 2020

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Tolerance to solid organ transplants through transfer of MHC class II genes

31 March 2020

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

31 March 2020

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Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

31 March 2020

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Identification of regulatory T cells in tolerated allografts

31 March 2020

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Regulatory T cells overexpress a subset of Th2 gene transcripts

31 March 2020

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Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells

31 March 2020

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Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes

31 March 2020

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B cells and professional APCs recruit regulatory T cells via CCL4

31 March 2020

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A very high level of crossreactivity is an essential feature of the T-cell receptor

31 March 2020

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Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium

31 March 2020

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Origin of regulatory T cells with known specificity for antigen

31 March 2020

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Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells

31 March 2020

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Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients

31 March 2020

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The role of the graft in establishing tolerance

31 March 2020

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Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

31 March 2020

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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

31 March 2020

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Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

31 March 2020

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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

31 March 2020

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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

31 March 2020

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A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance

31 March 2020

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Transforming growth factor-beta and interleukin-10 subvert alloreactive delayed type hypersensitivity in cardiac allograft acceptor mice

31 March 2020

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A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

31 March 2020

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Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

31 March 2020

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

31 March 2020

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CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

31 March 2020

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Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.

31 March 2020

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CTLA-4 can function as a negative regulator of T cell activation

31 March 2020

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

31 March 2020

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

31 March 2020

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

31 March 2020

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Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

31 March 2020

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Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood

31 March 2020

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

31 March 2020

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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

31 March 2020

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‘Anergic’ T cells Modulate the T-cell Activating Capacity of Antigen-presenting Cells

31 March 2020

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Human anergic CD4+ T cells can act as suppressor cells by affecting autologous dendritic cell conditioning and survival.

31 March 2020

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Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.

31 March 2020

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Control of regulatory T cell development by the transcription factor Foxp3

31 March 2020

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Transcription: tantalizing times for T cells

31 March 2020

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Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

31 March 2020

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

31 March 2020

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Interleukin 2 signaling is required for CD4(+) regulatory T cell function

31 March 2020

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Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.

31 March 2020

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Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

31 March 2020

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Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients

31 March 2020

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Weaning of immunosuppression in living donor liver transplant recipients

31 March 2020

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Sparing of suppressor cells: a critical action of cyclosporine

31 March 2020

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The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts

31 March 2020

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A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood

31 March 2020

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In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

31 March 2020

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In vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH)

31 March 2020

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The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality

31 March 2020

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Multiple levels of peripheral tolerance

31 March 2020

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Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells.

31 March 2020

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The effect of intrathymic injection of donor blood on the graft versus host reaction and cardiac allograft survival in the rat.

31 March 2020

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Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance

31 March 2020

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Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen

31 March 2020

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Anergic T cells as suppressor cells in vitro

31 March 2020

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High-dose/activation-associated tolerance: a mechanism for allograft tolerance

31 March 2020

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Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

31 March 2020

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CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells

31 March 2020

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CTLA-4 is a second receptor for the B cell activation antigen B7

31 March 2020

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The role of the CD28 receptor during T cell responses to antigen

31 March 2020

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Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

31 March 2020

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A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

31 March 2020

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Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo

31 March 2020

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Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1027

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release_wciopqvpkna4lfivygsu25drwi

6 August 2017

Fatcat ID

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24 November 2022

based on heuristic

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