(Q34926596)

5 August 2017

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title

A three-dimensional view of the molecular machinery of RNA interference (English)

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5 August 2017

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1

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5 August 2017

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Jennifer A Doudna

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5 August 2017

language of work or name

English

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publication date

1 January 2009

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5 August 2017

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5 August 2017

volume

457

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5 August 2017

issue

7228

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5 August 2017

page(s)

405-412

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Disruption of GW bodies impairs mammalian RNA interference

5 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1038%2FNATURE07755

A role for the P-body component GW182 in microRNA function

21 January 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNATURE07755

Dicer-2 and R2D2 coordinately bind siRNA to promote assembly of the siRISC complexes

21 January 2018

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12 December 2020

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage

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12 December 2020

Structural basis for double-stranded RNA processing by Dicer

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12 December 2020

Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage

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12 December 2020

How do microRNAs regulate gene expression?

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12 December 2020

Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila

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12 December 2020

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

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12 December 2020

Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini.

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12 December 2020

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

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12 December 2020

Crystal structure of human DGCR8 core

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12 December 2020

Cleavage of the siRNA passenger strand during RISC assembly in human cells

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12 December 2020

RNA interference against viruses: strike and counterstrike

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12 December 2020

Transcription and RNA interference in the formation of heterochromatin.

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12 December 2020

The nuclear RNase III Drosha initiates microRNA processing

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12 December 2020

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

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12 December 2020

Structure and conserved RNA binding of the PAZ domain

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12 December 2020

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

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12 December 2020

Virus counterdefense: diverse strategies for evading the RNA-silencing immunity

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12 December 2020

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

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12 December 2020

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

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12 December 2020

A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila

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12 December 2020

RNAi: the nuts and bolts of the RISC machine

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12 December 2020

MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F

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12 December 2020

A human, ATP-independent, RISC assembly machine fueled by pre-miRNA

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12 December 2020

Ribonuclease revisited: structural insights into ribonuclease III family enzymes

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12 December 2020

Prediction of mammalian microRNA targets

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12 December 2020

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

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12 December 2020

RNAi in human cells: basic structural and functional features of small interfering RNA.

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12 December 2020

Small non-coding RNAs in animal development

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12 December 2020

ATP requirements and small interfering RNA structure in the RNA interference pathway

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12 December 2020

Argonaute slicing is required for heterochromatic silencing and spreading

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12 December 2020

Specificity of ARGONAUTE7-miR390 interaction and dual functionality in TAS3 trans-acting siRNA formation

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12 December 2020

Perspective: machines for RNAi

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12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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12 December 2020

The RNA-induced silencing complex is a Mg2+-dependent endonuclease.

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12 December 2020

Specificity of microRNA target selection in translational repression

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12 December 2020

Crystal structure of Argonaute and its implications for RISC slicer activity

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12 December 2020

Purified Argonaute2 and an siRNA form recombinant human RISC

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12 December 2020

Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells

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12 December 2020

RISC assembly defects in the Drosophila RNAi mutant armitage.

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12 December 2020

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells

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12 December 2020

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

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12 December 2020

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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12 December 2020

A microRNA in a multiple-turnover RNAi enzyme complex

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12 December 2020

Structure of the guide-strand-containing argonaute silencing complex

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12 December 2020

Autoinhibition of human dicer by its internal helicase domain

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12 December 2020

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

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12 December 2020

Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila

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12 December 2020

Kinetic analysis of the RNAi enzyme complex

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12 December 2020

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

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12 December 2020

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

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12 December 2020

Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage

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12 December 2020

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

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12 December 2020

The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members

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12 December 2020

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

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12 December 2020

Asymmetry in the assembly of the RNAi enzyme complex

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12 December 2020

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

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12 December 2020

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

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12 December 2020

RISC is a 5' phosphomonoester-producing RNA endonuclease

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12 December 2020

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain

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12 December 2020

Structural insight into the mechanism of double-stranded RNA processing by ribonuclease III.

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12 December 2020

Identification of Drosophila MicroRNA targets

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12 December 2020

The Drosha-DGCR8 complex in primary microRNA processing

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12 December 2020

In vitro reconstitution of the human RISC-loading complex

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12 December 2020

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

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12 December 2020

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

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12 December 2020

Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

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12 December 2020

Ribonuclease activity and RNA binding of recombinant human Dicer

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12 December 2020

Single processing center models for human Dicer and bacterial RNase III

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12 December 2020

Argonaute proteins: key players in RNA silencing

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12 December 2020

Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein

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12 December 2020

Structural determinants of RNA recognition and cleavage by Dicer

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12 December 2020

Sorting of Drosophila small silencing RNAs

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12 December 2020

RNA helicases--one fold for many functions

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12 December 2020

Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1.

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12 December 2020

An mRNA m7G cap binding-like motif within human Ago2 represses translation

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12 December 2020

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

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12 December 2020

Identification of novel argonaute-associated proteins

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12 December 2020

Biogenesis and germline functions of piRNAs

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12 December 2020

Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex

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12 December 2020

Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide

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12 December 2020

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

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12 December 2020

The 3' termini of mouse Piwi-interacting RNAs are 2'-O-methylated

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12 December 2020

Argonaute2 is the catalytic engine of mammalian RNAi

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12 December 2020

Role for a bidentate ribonuclease in the initiation step of RNA interference

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12 December 2020

Slicer function of Drosophila Argonautes and its involvement in RISC formation

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12 December 2020

siRNAs can function as miRNAs

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12 December 2020

Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome

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12 December 2020

RNA interference is mediated by 21- and 22-nucleotide RNAs

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12 December 2020

The Microprocessor complex mediates the genesis of microRNAs

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12 December 2020

Identifiers

DOI

10.1038/NATURE07755

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5 August 2017

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