(Q34790350)

4 August 2017

title

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut (English)

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4 August 2017

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12

Shuh Narumiya

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4 August 2017

Kenji Kabashima

1

1 reference

4 August 2017

Tomomi Saji

2

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4 August 2017

Takahiko Murata

3

1 reference

4 August 2017

Miyako Nagamachi

4

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4 August 2017

Toshiyuki Matsuoka

5

1 reference

4 August 2017

Eri Segi

6

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4 August 2017

Kazuhito Tsuboi

7

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4 August 2017

Yukihiko Sugimoto

8

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4 August 2017

Takuya Kobayashi

9

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4 August 2017

Yoshiki Miyachi

10

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4 August 2017

Atsushi Ichikawa

11

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4 August 2017

language of work or name

English

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publication date

1 April 2002

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Journal of Clinical Investigation

4 August 2017

published in

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4 August 2017

volume

109

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4 August 2017

issue

7

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4 August 2017

page(s)

883-893

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Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestine lamina propria: directing the tone of the intestinal immune response

4 August 2017

cites work

1 reference

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Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors

8 July 2018

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Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea

8 July 2018

1 reference

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Prostanoids in human colonic mucosa: effects of inflammation on PGE(2) receptor expression

8 July 2018

1 reference

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Eicosanoids and the large intestine

8 July 2018

1 reference

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The biology of chemokines and their receptors

8 July 2018

1 reference

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Measurement of in vivo rectal mucosal cytokine and eicosanoid production in ulcerative colitis using filter paper

8 July 2018

1 reference

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Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.

8 July 2018

1 reference

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Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

8 July 2018

1 reference

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Prostanoid receptors: structures, properties, and functions

8 July 2018

2 references

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8 July 2018

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Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Inflammatory bowel disease: etiology and pathogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Inflammatory bowel disease incidence: up, down or unchanged?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Altered pain perception and inflammatory response in mice lacking prostacyclin receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Clinicopathologic study of dextran sulfate sodium experimental murine colitis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Intestinal transmission of macromolecules (BSA and FITC-labelled dextrans) in the neonatal pig. Influence of age of piglet and molecular weight of markers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Treatment with 16,16'-dimethyl prostaglandin E2 before and after induction of colitis with trinitrobenzenesulfonic acid in rats decreases inflammation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150928

Effects of ulcerative colitis activity on plasma and mucosal prostaglandin E2 concentration

26 October 2018

1 reference

12 December 2020

Prostaglandin D2 as a mediator of allergic asthma

1 reference

12 December 2020

Effects of nonsteroidal antiinflammatory drugs on inflammatory bowel disease: a case-control study

1 reference

12 December 2020

Prostaglandin E(2) receptors, EP2 and EP4, differentially modulate TNF-alpha and IL-6 production induced by lipopolysaccharide in mouse peritoneal neutrophils

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease

1 reference

12 December 2020

Misoprostol provides a colonic mucosal protective effect during acetic acid-induced colitis in rats

1 reference

12 December 2020

Experimental models of inflammatory bowel disease

1 reference

12 December 2020

Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: effects in CD4(+) -cell depleted, athymic and NK-cell depleted SCID mice

1 reference

12 December 2020

Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice

1 reference

12 December 2020

Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice

1 reference

12 December 2020

COX-2: promoting tolerance

1 reference

12 December 2020

Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI0214459

1 reference

4 August 2017

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4 August 2017

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