(Q34755720)

4 August 2017

title

Neprilysin-2 is an important β-amyloid degrading enzyme (English)

1 reference

4 August 2017

5

Edward Rockenstein

1 reference

4 August 2017

9

Eliezer Masliah

1 reference

4 August 2017

10

Robert A Marr

1 reference

author name string

Daniel Hafez

1

1 reference

4 August 2017

Jeffrey Y Huang

2

1 reference

4 August 2017

Alexis M Huynh

3

1 reference

4 August 2017

Stephanie Valtierra

4

1 reference

4 August 2017

Angela M Bruno

6

1 reference

4 August 2017

Bao Lu

7

1 reference

4 August 2017

Luc DesGroseillers

8

1 reference

4 August 2017

language of work or name

English

0 references

publication date

23 December 2010

1 reference

The American Journal of Pathology

4 August 2017

published in

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4 August 2017

volume

178

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4 August 2017

issue

1

1 reference

4 August 2017

page(s)

306-312

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Probing the biology of Alzheimer's disease in mice

4 August 2017

cites work

1 reference

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7 July 2018

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Forecasting the global burden of Alzheimer’s disease

7 July 2018

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Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease

7 July 2018

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Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase

7 July 2018

1 reference

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Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

7 July 2018

1 reference

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Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease

7 July 2018

1 reference

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Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

7 July 2018

1 reference

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Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40.

7 July 2018

1 reference

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Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, an

7 July 2018

1 reference

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Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2.

7 July 2018

1 reference

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Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease

7 July 2018

1 reference

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New insights into the roles of metalloproteinases in neurodegeneration and neuroprotection

7 July 2018

1 reference

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Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo

7 July 2018

1 reference

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Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

7 July 2018

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A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade

7 July 2018

1 reference

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Reduced fertility in male mice deficient in the zinc metallopeptidase NL1

7 July 2018

1 reference

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

7 July 2018

1 reference

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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

7 July 2018

1 reference

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Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Alternative splicing regulates the endoplasmic reticulum localization or secretion of soluble secreted endopeptidase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Neutral endopeptidase modulation of septic shock.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

A new technique for the assay of infectivity of human adenovirus 5 DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Neprilysin deficiency-dependent impairment of cognitive functions in a mouse model of amyloidosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Activation of the amyloid cascade by intracerebroventricular injection of the protease inhibitor phosphoramidon

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

The neuropeptide-degrading enzyme NL1 is expressed in specific neurons of mouse brain

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Metabolic regulation of brain Abeta by neprilysin

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNFα

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069828

Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21224067

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.AJPATH.2010.11.012

1 reference

4 August 2017

1 reference

4 August 2017

1 reference