(Q34750615)

4 August 2017

1 reference

title

Is gamma-secretase a multienzyme complex for membrane protein degradation? Models and speculations (English)

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4 August 2017

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David H Small

1

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4 August 2017

language of work or name

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1 July 2002

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4 August 2017

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4 August 2017

volume

23

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4 August 2017

issue

7

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4 August 2017

page(s)

1317-1321

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

The multiple paradoxes of presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

The role of presenilins in gamma-secretase activity: catalyst or cofactor?

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Presenilin and gamma-secretase: structure meets function

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900072-4

7 January 2021

10.1016/S0196-9781(02)00072-4

Identifiers

DOI

1 reference

4 August 2017

1 reference