(Q34707977)

4 August 2017

1 reference

title

Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes (English)

1 reference

4 August 2017

Ian H Gilbert

1

0 references

language of work or name

English

0 references

publication date

1 July 2002

1 reference

Biochimica et Biophysica Acta

4 August 2017

published in

1 reference

4 August 2017

volume

1587

1 reference

4 August 2017

issue

2-3

1 reference

4 August 2017

page(s)

249-257

1 reference

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Heterologous expression of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania major

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Cloning and expression of the dihydrofolate reductase-thymidylate synthase gene from Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Thymidylate synthase-dihydrofolate reductase in protozoa

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Biochemical and Genetic Tests for Inhibitors ofLeishmaniaPteridine Pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Substrate channeling and domain-domain interactions in bifunctional thymidylate synthase-dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Dihydrofolate reductases within the genus Trypanosoma

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

An in-vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Effects of methotrexate and other antifolates on the growth and dihydrofolate reductase activity of Leishmania promastigotes

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Antileishmanial activities of 2,4-diaminoquinazoline putative dihydrofolate reductase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Antimalarial drugs. 24. Folate antagonists. 2. 2,4-Diamino-6-{[aralkyl and (heterocyclic)methyl]amino}quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Folate antagonists. 9. 2,4-Diamino-6-[(aralkyl)alkylamino]quniazolines, a potent class of antimetabolites with prodigious antimalarial effects

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

PAM 1392 [2,4-diamino-6-(3,4-dichlorobenzylamino) Quinazoline] as a chemotherapeutic agent: Plasmodium berghei, P. cynomolgi, P. knowlesi, and Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Novel inhibitors of Leishmanial dihydrofolate reductase.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Structure-based strategies for drug design and discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

A novel antifolate resistance gene on the amplified H circle of Leishmania.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900088-1

7 January 2021

10.1016/S0925-4439(02)00088-1

Identifiers

DOI

1 reference

4 August 2017

1 reference