(Q34598464)

3 August 2017

title

Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production (English)

1 reference

3 August 2017

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4

Arthur Weiss

1 reference

3 August 2017

David G T Hesslein

1

1 reference

3 August 2017

Rayna Takaki

series ordinal

2

1 reference

3 August 2017

Michelle L Hermiston

series ordinal

3

1 reference

3 August 2017

Lewis L Lanier

series ordinal

5

1 reference

3 August 2017

language of work or name

English

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publication date

20 April 2006

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3 August 2017

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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3 August 2017

volume

103

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3 August 2017

issue

18

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3 August 2017

page(s)

7012-7017

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A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells

3 August 2017

cites work

1 reference

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7 July 2018

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The low affinity Fc receptor for IgG functions as an effective cytolytic receptor for self-specific CD8 T cells.

7 July 2018

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Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity

7 July 2018

1 reference

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Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Natural killer cell receptor signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Molecular mechanisms regulating Th1 immune responses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

CD45: a critical regulator of signaling thresholds in immune cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Recognition of a virus-encoded ligand by a natural killer cell activation receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

MAP kinases in the immune response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Differential role of p38 and c-Jun N-terminal kinase 1 mitogen-activated protein kinases in NK cell cytotoxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

An activating immunoreceptor complex formed by NKG2D and DAP10

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

The regulatory role of CD45 on rat NK cells in target cell lysis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

CD45-mediated regulation of LFA1 function in human natural killer cells. Anti-CD45 monoclonal antibodies inhibit the calcium mobilization induced via LFA1 molecules

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

CD45-cross-linking stimulates IFN-gamma production in NK cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Cross-linking of CD45 on NK cells stimulates p56lck-mediated tyrosine phosphorylation and IFN-gamma production

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

CD45 molecule cross-linking inhibits natural killer cell-mediated lysis independently of lytic triggering

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459010

Activating Ly-49 NK receptors: central role in cytokine and chemokine production

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

Development of intestinal intraepithelial lymphocytes, NK cells, and NK 1.1+ T cells in CD45-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

Molecular Competition for NKG2D

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

Impairment of NK cell function by NKG2D modulation in NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0601851103

Inhibition of natural killer-cell mediated cytolysis with monoclonal antibodies to restricted and non-restricted epitopes of the leucocyte common antigen

21 January 2018

1 reference

12 December 2020

Enhanced generation of NK cells with intact cytotoxic function in CD45 exon 6-deficient mice

1 reference

12 December 2020

Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal-regulated kinases

1 reference

12 December 2020

Regulation of p38 mitogen-activated protein kinase during NK cell activation

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0601851103

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3 August 2017

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3 August 2017

1 reference