(Q34572339)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25018104%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25018104%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

main subject

endoplasmic reticulum

0 references

author

Aeid Igbaria

5

1 reference

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9 March 2020

Marcel V. Alavi

13

1 reference

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9 March 2020

Sanjay B. Hari

14

1 reference

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9 March 2020

Barun Bhhatarai

16

1 reference

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9 March 2020

Dustin J. Maly

22

1 reference

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9 March 2020

author name string

Rajarshi Ghosh

1

1 reference

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9 March 2020

Likun Wang

2

1 reference

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9 March 2020

Eric S Wang

3

1 reference

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9 March 2020

B Gayani K Perera

4

1 reference

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9 March 2020

Shuhei Morita

6

1 reference

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9 March 2020

Kris Prado

7

1 reference

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9 March 2020

Maike Thamsen

8

1 reference

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9 March 2020

Deborah Caswell

9

1 reference

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9 March 2020

Hector Macias

10

1 reference

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9 March 2020

Kurt F Weiberth

11

1 reference

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9 March 2020

Micah J Gliedt

12

1 reference

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9 March 2020

Arinjay K Mitra

15

1 reference

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9 March 2020

Stephan C Schürer

17

1 reference

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9 March 2020

Douglas B Gould

19

1 reference

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9 March 2020

Michael S German

20

1 reference

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9 March 2020

Bradley J Backes

21

1 reference

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9 March 2020

Scott A Oakes

23

1 reference

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9 March 2020

Feroz R Papa

24

1 reference

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9 March 2020

Erik L Snapp

18

1 reference

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9 March 2020

language of work or name

English

0 references

publication date

10 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25018104%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25018104%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

volume

158

1 reference

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9 March 2020

issue

3

1 reference

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9 March 2020

page(s)

534-548

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25018104%20AND%20SRC:MED&resulttype=core&format=json

Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration

9 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Signaling cell death from the endoplasmic reticulum stress response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

The NLRP3 inflammasome: a sensor for metabolic danger?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Divergent effects of PERK and IRE1 signaling on cell viability

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

The unfolded protein response signals through high-order assembly of Ire1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

IRE1 signaling affects cell fate during the unfolded protein response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

How transmembrane proteins sense endoplasmic reticulum stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Involvement of ER stress in retinal cell death

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Patterns of somatic mutation in human cancer genomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

RIP1, a kinase on the crossroads of a cell's decision to live or die

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

On the mechanism of sensing unfolded protein in the endoplasmic reticulum

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Plasma cell differentiation requires the transcription factor XBP-1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Regulated translation initiation controls stress-induced gene expression in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

Murine pancreatic islet isolation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

10.1016/J.CELL.2014.07.002

27 October 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25018104%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25018104%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

25018104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25018104%20AND%20SRC:MED&resulttype=core&format=json