(Q34572193)

3 August 2017

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title

Cytokines and immunodeficiency diseases (English)

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3 August 2017

W J Leonard

1

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3 August 2017

publication date

1 December 2001

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

1

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3 August 2017

issue

3

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3 August 2017

page(s)

200-208

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The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling

3 August 2017

cites work

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Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.

21 January 2018

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Naturally occurring primary deficiencies of the immune system

21 January 2018

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

21 January 2018

1 reference

Gene therapy for human severe combined immunodeficiencies

21 January 2018

1 reference

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

21 January 2018

1 reference

Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13.

21 January 2018

1 reference

Cloning of the gamma chain of the human IL-2 receptor

21 January 2018

1 reference

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

21 January 2018

1 reference

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease

21 January 2018

1 reference

Severe combined immunodeficiency due to a specific defect in the production of interleukin-2

21 January 2018

1 reference

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

21 January 2018

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Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

21 January 2018

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Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

21 January 2018

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Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes

21 January 2018

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Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

21 January 2018

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Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex

21 January 2018

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Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

21 January 2018

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The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.

21 January 2018

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STATs and Gene Regulation

21 January 2018

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The state of the STATs: recent developments in the study of signal transduction to the nucleus

21 January 2018

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Jaks and STATs: biological implications

21 January 2018

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Complex roles of Stat1 in regulating gene expression

21 January 2018

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

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Signal transduction through NF-kappa B.

21 January 2018

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Manipulating immune responses with immunosuppressive agents that target NFAT.

21 January 2018

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Transcriptional control by the TGF-beta/Smad signaling system

21 January 2018

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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

21 January 2018

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Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

21 January 2018

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Negative regulators of cytokine signaling

21 January 2018

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Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

21 January 2018

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Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

21 January 2018

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Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

21 January 2018

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Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

21 January 2018

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Genomic sequence, organization, and chromosomal localization of human JAK3.

21 January 2018

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Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

21 January 2018

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Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

21 January 2018

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The role of Jak3 in lymphoid development, activation, and signaling

21 January 2018

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Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice

21 January 2018

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Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

21 January 2018

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Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

21 January 2018

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Generation and analysis of interleukin-4 deficient mice

21 January 2018

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IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development

21 January 2018

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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

21 January 2018

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Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

21 January 2018

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Jak2 is essential for signaling through a variety of cytokine receptors

21 January 2018

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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

21 January 2018

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Partial impairment of cytokine responses in Tyk2-deficient mice

21 January 2018

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Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

21 January 2018

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Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

21 January 2018

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

21 January 2018

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Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation

21 January 2018

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

21 January 2018

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

21 January 2018

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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

21 January 2018

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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

21 January 2018

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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

21 January 2018

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Stat5a is mandatory for adult mammary gland development and lactogenesis.

21 January 2018

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Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

21 January 2018

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Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

21 January 2018

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Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells

21 January 2018

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Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity

21 January 2018

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Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements

21 January 2018

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Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene

21 January 2018

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The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements

21 January 2018

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Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

21 January 2018

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Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency

21 January 2018

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Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers

21 January 2018

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Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

21 January 2018

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Mutations in the gene for the IL-7 receptor result in T(-)B(+)NK(+) severe combined immunodeficiency disease

21 January 2018

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Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

21 January 2018

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Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

21 January 2018

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Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

21 January 2018

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PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice

21 January 2018

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Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

21 January 2018

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Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor

21 January 2018

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Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection

21 January 2018

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Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

21 January 2018

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Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis

21 January 2018

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Partial Interferon‐γ Receptor Signaling Chain Deficiency in a Patient with Bacille Calmette‐Guérin andMycobacterium abscessusInfection

21 January 2018

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Haemopoietic receptors and helical cytokines

21 January 2018

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Three-dimensional structure of recombinant human interferon-gamma

21 January 2018

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Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site

21 January 2018

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Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

21 January 2018

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JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

21 January 2018

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Structure of the amino-terminal protein interaction domain of STAT-4

21 January 2018

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The significance of tetramerization in promoter recruitment by Stat5.

21 January 2018

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Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons

21 January 2018

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Roles of STAT3 defined by tissue-specific gene targeting

21 January 2018

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Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

21 January 2018

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Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants

21 January 2018

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7 January 2021

Preface: STAT signaling

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7 January 2021

Inhibitors keep cytokines in check

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7 January 2021

Defective lymphoid development in mice lacking Jak3

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7 January 2021

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

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7 January 2021

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

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7 January 2021

Immune response in Stat2 knockout mice

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7 January 2021

Interleukin-3 signals through multiple isoforms of Stat5.

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7 January 2021

Interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 transduce signals through two forms of STAT5.

1 reference

7 January 2021

An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction

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7 January 2021

Human IL-2 receptor alpha chain deficiency

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7 January 2021

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

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7 January 2021

Cytokines and their receptor complexes.

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7 January 2021

Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes

1 reference

7 January 2021

Identifiers

DOI

10.1038/35105066

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3 August 2017

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