(Q34556342)

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Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

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Europe PubMed Central

PubMed publication ID

3 August 2017

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Sylviane Olschwang

8

object named as

Sylviane Olschwang

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Europe PubMed Central

PubMed publication ID

3 August 2017

Sandrine Etienne-Manneville

2

object named as

Sandrine Etienne-Manneville

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Europe PubMed Central

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3 August 2017

author name string

Christelle Forcet

1

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Europe PubMed Central

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3 August 2017

Hélène Gaude

3

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Europe PubMed Central

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3 August 2017

Laurence Fournier

4

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Europe PubMed Central

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3 August 2017

Sébastien Debilly

5

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Marko Salmi

6

1 reference

Europe PubMed Central

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3 August 2017

Annette Baas

7

1 reference

Europe PubMed Central

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3 August 2017

Hans Clevers

9

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Europe PubMed Central

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3 August 2017

Marc Billaud

10

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3 August 2017

publication date

30 March 2005

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Europe PubMed Central

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3 August 2017

Human Molecular Genetics

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Europe PubMed Central

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3 August 2017

14

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Europe PubMed Central

PubMed publication ID

3 August 2017

10

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Europe PubMed Central

PubMed publication ID

3 August 2017

1283-1292

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Europe PubMed Central

PubMed publication ID

3 August 2017

Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Increased risk of cancer in the Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Cancer and the Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

LKB1 (XEEK1) regulates Wnt signalling in vertebrate development

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

The AMP-activated protein kinase cascade--a unifying system for energy control

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Analysis of the LKB1-STRAD-MO25 complex

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

The LKB1 tumor suppressor negatively regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

LKB1, a protein kinase regulating cell proliferation and polarity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

LKB1--a master tumour suppressor of the small intestine and beyond

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI139

21 January 2018

Identifiers

10.1093/HMG/DDI139

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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