(Q34278940)

1 August 2017

title

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. (English)

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1 August 2017

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Nahum Sonenberg

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1 August 2017

Marc R Fabian

1

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1 August 2017

publication date

5 June 2012

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Nature Structural & Molecular Biology

1 August 2017

published in

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1 August 2017

volume

19

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1 August 2017

issue

6

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1 August 2017

page(s)

586-593

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MicroRNAs: target recognition and regulatory functions

1 August 2017

cites work

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Regulation of mRNA translation and stability by microRNAs

21 January 2018

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Getting to the root of miRNA-mediated gene silencing

21 January 2018

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

21 January 2018

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MicroRNA-repressed mRNAs contain 40S but not 60S components

21 January 2018

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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

21 January 2018

1 reference

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.

21 January 2018

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Inhibition of translational initiation by Let-7 MicroRNA in human cells

21 January 2018

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Human let-7a miRNA blocks protein production on actively translating polyribosomes

21 January 2018

1 reference

Short RNAs repress translation after initiation in mammalian cells.

21 January 2018

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The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

21 January 2018

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Evidence that microRNAs are associated with translating messenger RNAs in human cells

21 January 2018

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MicroRNAs direct rapid deadenylation of mRNA

21 January 2018

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Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps

21 January 2018

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Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs

21 January 2018

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

21 January 2018

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A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

21 January 2018

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MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

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Crystal structure of Argonaute and its implications for RISC slicer activity

21 January 2018

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Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells

21 January 2018

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Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

21 January 2018

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GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

21 January 2018

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A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

21 January 2018

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Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

21 January 2018

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Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

21 January 2018

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The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing

21 January 2018

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Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components.

21 January 2018

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The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

21 January 2018

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miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs

21 January 2018

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The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression

21 January 2018

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The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing

21 January 2018

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Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

21 January 2018

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Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila

21 January 2018

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A C-terminal silencing domain in GW182 is essential for miRNA function

21 January 2018

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Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.

21 January 2018

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Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

21 January 2018

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The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release

21 January 2018

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miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

21 January 2018

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Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

21 January 2018

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The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans

21 January 2018

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Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

21 January 2018

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A role for the P-body component GW182 in microRNA function

21 January 2018

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GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

21 January 2018

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Regulation of poly(A)-binding protein through PABP-interacting proteins.

21 January 2018

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Solution structure of the PABC domain from wheat poly (A)-binding protein: an insight into RNA metabolic and translational control in plants

21 January 2018

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BTG/TOB factors impact deadenylases

21 January 2018

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Structure and function of the C-terminal PABC domain of human poly(A)-binding protein

21 January 2018

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Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein

21 January 2018

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Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.

21 January 2018

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Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression

21 January 2018

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PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro

21 January 2018

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Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system

21 January 2018

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Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families.

21 January 2018

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CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells

21 January 2018

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Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing

21 January 2018

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General translational repression by activators of mRNA decapping

21 January 2018

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Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

21 January 2018

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

21 January 2018

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Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

21 January 2018

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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

21 January 2018

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Relief of microRNA-mediated translational repression in human cells subjected to stress

21 January 2018

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Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

21 January 2018

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Deadenylation is a widespread effect of miRNA regulation

21 January 2018

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Widespread changes in protein synthesis induced by microRNAs

21 January 2018

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The impact of microRNAs on protein output

21 January 2018

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Identifying targets of miR-143 using a SILAC-based proteomic approach

21 January 2018

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Mammalian microRNAs predominantly act to decrease target mRNA levels

21 January 2018

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Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA

21 January 2018

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A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation

21 January 2018

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Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression

21 January 2018

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miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay

21 January 2018

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Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish

21 January 2018

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Widespread use of poly(A) tail length control to accentuate expression of the yeast transcriptome

21 January 2018

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Allosteric regulation of Argonaute proteins by miRNAs.

21 January 2018

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An mRNA m7G cap binding-like motif within human Ago2 represses translation

21 January 2018

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A parsimonious model for gene regulation by miRNAs.

21 January 2018

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The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif

21 January 2018

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Structural analysis of 5′-mRNA–cap interactions with the human AGO2 MID domain

21 January 2018

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Translational repression by deadenylases

21 January 2018

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HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis

21 January 2018

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HuR recruits let-7/RISC to repress c-Myc expression

21 January 2018

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Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression

21 January 2018

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Competitive regulation of nucleolin expression by HuR and miR-494

21 January 2018

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The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.

21 January 2018

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Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430.

21 January 2018

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RNA-binding protein Dnd1 inhibits microRNA access to target mRNA

21 January 2018

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The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1

21 January 2018

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A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility

21 January 2018

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Riboswitch RNAs: using RNA to sense cellular metabolism

21 January 2018

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The structural and functional diversity of metabolite-binding riboswitches

21 January 2018

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Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system

21 January 2018

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PUF proteins bind Pop2p to regulate messenger RNAs

21 January 2018

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Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability

21 January 2018

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Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.

21 January 2018

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Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA.

21 January 2018

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Spinocerebellar ataxia 2 (SCA2).

21 January 2018

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The Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation.

21 January 2018

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MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F

21 January 2018

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Mapping of Ago2-GW182 functional interactions

21 January 2018

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The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes

31 March 2020

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HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.

31 March 2020

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PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB.2296

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1 August 2017

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