(Q34265967)

1 August 2017

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title

The clinical pharmacology of 6-mercaptopurine (English)

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1 August 2017

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L. Lennard

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1451710

28 September 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1451710

28 September 2022

publication date

1 January 1992

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European Journal of Clinical Pharmacology

1 August 2017

published in

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1 August 2017

volume

43

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1 August 2017

issue

4

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1 August 2017

page(s)

329-339

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Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients

1 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FBF02220605

Effect of allopurinol on caffeine disposition in man.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02220605

Azathioprine metabolism in kidney transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02220605

Metabolism of azathioprine to 6-thioguanine nucleotides in patients with pemphigus vulgaris

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02220605

Effect of 6-mercaptopurine on antibody production

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FBF02220605

21 January 2018

12 December 2020

Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia

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https://api.crossref.org/works/10.1007%2FBF02220605

Azathioprine suppresses the mixed lymphocyte reaction of patients with Lesch-Nyhan syndrome

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02220605

Azathioprine, a genotoxic agent to be considered non-genotoxic in man.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02220605

Variables and Paradoxes in “Maintenance” Therapy of Lymphoblastic Leukemia

21 January 2018

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12 December 2020

Assignment of Nucleoside Phosphorylase to D-14 and Localization of X-linked Loci in Man by Somatic Cell Genetics

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12 December 2020

A study of the effects of drugs in prolonging survival of homologous renal transplants in dogs

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12 December 2020

Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

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12 December 2020

Formation and significance of 6-methylthiopurine ribonucleotide as a metabolite of 6-mercaptopurine

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12 December 2020

The Effects of Azathioprine and 6 mp on Immunity

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12 December 2020

Xanthine oxidase: biochemistry, distribution and physiology

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12 December 2020

Drug dosage and remission duration in childhood lymphocytic leukemia

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12 December 2020

Assay of 6-mercaptopurine in human plasma

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12 December 2020

Variability in caffeine metabolism

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12 December 2020

Chromatographic analysis of anticancer drugs

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12 December 2020

6-Thioguanine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells

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12 December 2020

Localization of loci for hypoxanthine phosphoribosyltransferase and glucose-6-phosphate dehydrogenase and biochemical evidence of nonrandom X chromosome expression from studies of a human X-autosome translocation

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12 December 2020

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity

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12 December 2020

Inhibition of mammalian xanthine oxidase by folate compounds and amethopterin.

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12 December 2020

Photochemical sensitization by azathioprine and its metabolites--I. 6-Mercaptopurine

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12 December 2020

Use of azathioprine or 6-mercaptopurine in the treatment of Crohn's disease

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12 December 2020

The effect of methotrexate on the bioavailability of oral 6-mercaptopurine

1 reference

12 December 2020

6-mercaptopurine plasma levels in children with acute lymphoblastic leukemia: relation to relapse risk and myelotoxicity

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12 December 2020

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

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12 December 2020

Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia

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12 December 2020

Azathioprine lymphocytotoxicity. Potentially lethal damage by its imidazole derivatives

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12 December 2020

Importance of 6-mercaptopurine dose in lymphoblastic leukaemia

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12 December 2020

Pyrroline-5-carboxylate stimulates the conversion of purine antimetabolites to their nucleotide forms by a redox-dependent mechanism

1 reference

12 December 2020

Immunosuppressive effects of specific classes of agents with special reference to organ transplantation. Immunosuppression by thiopurines

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12 December 2020

Pharmacokinetics of mercaptopurine in children with acute lymphocytic leukemia

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12 December 2020

Activities of immunosuppressive agents in vitro. II. Different timing of azathioprine and methotrexate in inhibition and stimulation of mixed lymphocyte reaction

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12 December 2020

Selective action of azathioprine on T cells

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12 December 2020

Minimal residual disease in childhood B-lineage lymphoblastic leukemia. Persistence of leukemic cells during the first 18 months of treatment

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12 December 2020

A reversed phase high performance liquid chromatography approach in determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in a patient receiving thiopurine therapy

1 reference

12 December 2020

Leukocyte purine phosphoribosyltransferases in human leukemias sensitive and resistant to 6-thiopurines

1 reference

12 December 2020

Quantitation of plasma azathioprine and 6-mercaptopurine levels in renal transplant patients

1 reference

12 December 2020

Purification and properties of 5-phosphoribosyl pyrophosphate amidotransferase from adenocarcinoma 755 cells

1 reference

12 December 2020

Controlled trial of azathioprine in Crohn's disease

1 reference

12 December 2020

Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases

1 reference

12 December 2020

The metabolism of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in man.

1 reference

12 December 2020

Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts

1 reference

12 December 2020

A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells

1 reference

12 December 2020

Oral 6-mercaptopurine in childhood leukemia: parent drug pharmacokinetics and active metabolite concentrations

1 reference

12 December 2020

Modulation of thiopurine cytotoxicity in the HL-60 cell line by physiological concentrations of hypoxanthine

1 reference

12 December 2020

Thiopurine methyltransferase biochemical genetics: human lymphocyte activity

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12 December 2020

Maintenance chemotherapy and cure of childhood acute lymphoblastic leukaemia

1 reference

12 December 2020

A 10-year matched-pairs study comparing azathioprine and no immunosuppression in multiple sclerosis

1 reference

12 December 2020

Overview of azathioprine treatment in multiple sclerosis

1 reference

12 December 2020

Concurrent unilateral chromatid damage and DNA strand breakage in response to 6-thioguanine treatment

1 reference

12 December 2020

Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study

1 reference

12 December 2020

Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

1 reference

12 December 2020

Human liver xanthine oxidase: Nature and extent of individual variation

1 reference

12 December 2020

Enhancement of UV-induced skin carcinogenesis by azathioprine: role of photochemical sensitisation.

1 reference

12 December 2020

Hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular basis of the clinical syndromes

1 reference

12 December 2020

Liver damage in children with acute leukaemia and non-Hodgkin's lymphoma on oral maintenance chemotherapy

1 reference

12 December 2020

Maintenance chemotherapy for childhood acute lymphoblastic leukemia: relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes

1 reference

12 December 2020

Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia

1 reference

12 December 2020

A clinically useful ion-pairing high-performance liquid chromatographic assay for the monophosphate metabolites of thioguanine and mercaptopurine in human neoplastic cells

1 reference

12 December 2020

6-Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia

1 reference

12 December 2020

A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine

1 reference

12 December 2020

Double-masked trial of azathioprine in multiple sclerosis. British and Dutch Multiple Sclerosis Azathioprine Trial Group

1 reference

12 December 2020

Metabolism of 6-mercaptopurine in human leukemic cells

1 reference

12 December 2020

Prolonged survival of human-kidney homografts by immunosuppressive drug therapy

1 reference

12 December 2020

Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.

1 reference

12 December 2020

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

1 reference

12 December 2020

Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?

1 reference

12 December 2020

Effect of methylthioinosine on nucleotide concentrations in L5178Y cells

1 reference

12 December 2020

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

1 reference

12 December 2020

Long-term 6-mercaptopurine treatment in adolescents with Crohn's disease

1 reference

12 December 2020

Pharmacokinetics of oral 6-mercaptopurine: relationship between plasma levels and urine excretion of parent drug

1 reference

12 December 2020

Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells

1 reference

12 December 2020

A phase II trial of continuous-infusion 6-mercaptopurine for childhood solid tumors

1 reference

12 December 2020

Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells

1 reference

12 December 2020

Studies on the mechanism of formation of 5-mercapto-1-methyl-4-nitroimidazole, a metabolite of the immunosuppressive drug azathioprine

1 reference

12 December 2020

Determination of 6-mercaptopurine in acute lymphoblastic leukemia patients' plasma by high-performance liquid chromatography

1 reference

12 December 2020

Controlled trial of azathioprine in Crohn's disease.

1 reference

12 December 2020

Phase I and clinical pharmacological study of mercaptopurine administered as a prolonged intravenous infusion

1 reference

12 December 2020

Mercaptopurine "bioavailability"

1 reference

12 December 2020

Studies on the xanthine oxidase activity of mammalian cells

1 reference

12 December 2020

Biochemical parameters of mercaptopurine activity in patients with acute lymphoblastic leukemia

1 reference

12 December 2020

Rat thiopurine methyltransferase: regulation by testosterone

1 reference

12 December 2020

Serum azathioprine and 6-mercaptopurine levels and immunosuppressive activity after azathioprine in uremic patients

1 reference

12 December 2020

DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS

1 reference

12 December 2020

Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children.

1 reference

12 December 2020

Improvement in treatment for children with acute lymphoblastic leukaemia. The Medical Research Council UKALL trials, 1972-84. Report to the Council by the Working Party on Leukaemia in Childhood

1 reference

12 December 2020

Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells.

1 reference

12 December 2020

Significance of azathioprine metabolites

1 reference

12 December 2020

Inhibition of first-pass metabolism in cancer chemotherapy: interaction of 6-mercaptopurine and allopurinol

1 reference

12 December 2020

Pharmacogenetics of methylation: relationship to drug metabolism

1 reference

12 December 2020

Effects of azathioprine in a disorder of uric acid metabolism and cerebral function

1 reference

12 December 2020

Are children with lymphoblastic leukaemia given enough 6-mercaptopurine?

1 reference

12 December 2020

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia

1 reference

12 December 2020

Pharmacogenetics of human thiopurine methyltransferase: kidney-erythrocyte correlation and immunotitration studies

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02220605

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Dimensions Publication ID

1 August 2017

1000863143

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