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HIV-1 protease: maturation, enzyme specificity, and drug resistance.
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Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
review article
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Europe PubMed Central
title
HIV-1 protease: maturation, enzyme specificity, and drug resistance
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
main subject
drug resistance
1 reference
based on heuristic
inferred from title
author
Angela Gronenborn
series ordinal
5
1 reference
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Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
author name string
J M Louis
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
I T Weber
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
J Tözsér
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
G M Clore
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
publication date
1 January 2000
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
published in
Advances in Pharmacology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
volume
49
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
page(s)
111-146
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
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Proteolytic processing mechanisms of a miniprecursor of the aspartic protease of human immunodeficiency virus type 1.
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7 January 2021
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Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins
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7 January 2021
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Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method
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Genetic locus, primary structure, and chemical synthesis of human immunodeficiency virus protease
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7 January 2021
based on heuristic
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HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
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The HIV-1 protease as a therapeutic target for AIDS
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Crossref
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7 January 2021
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Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors
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Crossref
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https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
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Subsite preferences of retroviral proteinases
1 reference
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Crossref
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7 January 2021
based on heuristic
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A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease.
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Crossref
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7 January 2021
based on heuristic
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Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites
1 reference
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7 January 2021
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Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure
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7 January 2021
based on heuristic
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Comparative analysis of the sequences and structures of HIV-1 and HIV-2 proteases
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
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Energy calculations and analysis of HIV-1 protease-inhibitor crystal structures
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
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Molecular characterization of gag proteins from simian immunodeficiency virus (SIVMne).
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7 January 2021
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Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
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7 January 2021
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Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor
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7 January 2021
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Human immunodeficiency virus-1 protease. 2. Use of pH rate studies and solvent kinetic isotope effects to elucidate details of chemical mechanism
1 reference
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https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
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inferred from DOI database lookup
Fidelity of HIV-1 reverse transcriptase copying RNA in vitro
1 reference
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Crossref
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7 January 2021
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Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartments
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of the HIV-1 gag-pol polyprotein results in intracellular activation of HIV-1 protease and inhibition of assembly and budding of virus-like particles
1 reference
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Crossref
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7 January 2021
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Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sub-site preferences of the aspartic proteinase from the human immunodeficiency virus, HIV-1.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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The HIV Protease and Therapies for AIDS
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays.
1 reference
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7 January 2021
based on heuristic
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Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors
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7 January 2021
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Standardized and simplified nomenclature for proteins common to all retroviruses
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7 January 2021
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Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Hydrophilic Peptides Derived from the Transframe Region of Gag-Pol Inhibit the HIV-1 Protease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Autoprocessing of the HIV-1 protease using purified wild-type and mutated fusion proteins expressed at high levels in Escherichia coli
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Substitution mutations of the highly conserved arginine 87 of HIV-1 protease result in loss of proteolytic activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolytic processing of HIV-1 protease precursor, kinetics and mechanism
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Q57904706
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Substitutions at the P2' site of gag p17-p24 affect cleavage efficiency by HIV-1 protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Peptide substrates and inhibitors of the HIV-1 protease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Retroviral proteinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A structural model for the retroviral proteases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hydrolysis of synthetic chromogenic substrates by HIV-1 and HIV-2 proteinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Intrinsic activity of precursor forms of HIV-1 proteinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The mechanism of action of aspartic proteases involves 'push-pull' catalysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Substrate-dependent mechanisms in the catalysis of human immunodeficiency virus protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of aspartic proteinases by synthetic peptides derived from the propart region of human prorenin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
In situ processing of a retroviral nucleocapsid protein by the viral proteinase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Three-dimensional structures of HIV-1 and SIV protease product complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
On the size of the active site in proteases. I. Papain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple Concurrent Reverse Transcriptase and Protease Mutations and Multidrug Resistance of HIV-1 Isolates from Heavily Treated Patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specificity of retroviral proteases: an analysis of viral and nonviral protein substrates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparative studies on the substrate specificity of avian myeloblastosis virus proteinase and lentiviral proteinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on the role of the S4 substrate binding site of HIV proteinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic and modeling studies of S3-S3' subsites of HIV proteinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activity of tethered human immunodeficiency virus 1 protease containing mutations in the flap region of one subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Viral dynamics in human immunodeficiency virus type 1 infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based inhibitors of HIV-1 protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influence of flanking sequences on the dimer stability of human immunodeficiency virus type 1 protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The gag precursor contains a specific HIV-1 protease cleavage site between the NC (P7) and P1 proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
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inferred from DOI database lookup
A transient precursor of the HIV-1 protease. Isolation, characterization, and kinetics of maturation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
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inferred from DOI database lookup
Structural Basis for Specificity of Retroviral Proteases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
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Secondary structure and signal assignments of human-immunodeficiency-virus-1 protease complexed to a novel, structure-based inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
retrieved
7 January 2021
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Loss of Viral Fitness Associated with Multiple Gag and Gag-Pol Processing Defects in Human Immunodeficiency Virus Type 1 Variants Selected for Resistance to Protease Inhibitors In Vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2949025-3
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7 January 2021
based on heuristic
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Identifiers
DOI
10.1016/S1054-3589(00)49025-3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
PubMed publication ID
11013762
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11013762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
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