(Q34048479)

30 July 2017

title

Reversal of experimental pulmonary hypertension by PDGF inhibition (English)

1 reference

30 July 2017

main subject

pulmonary hypertension

1 reference

Akylbek Sydykov

7

0 references

Soni Savai Pullamsetti

Soni Pullamsetti

4

0 references

Norbert Weissmann

Norbert Weissmann

9

0 references

Ralph T Schermuly

Ralph Theo Schermuly

1

0 references

Friedrich Grimminger

Friedrich Grimminger

11

0 references

Werner Seeger

Werner Seeger

10

0 references

Hossein A Ghofrani

3

Hossein Ardeschir Ghofrani

1 reference

30 July 2017

5

Rajkumar Savai

1 reference

30 July 2017

2

Eva Dony

1 reference

30 July 2017

Markus Roth

6

1 reference

30 July 2017

Ying Ju Lai

8

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 October 2005

1 reference

Journal of Clinical Investigation

30 July 2017

published in

1 reference

30 July 2017

volume

115

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30 July 2017

issue

10

1 reference

30 July 2017

page(s)

2811-2821

1 reference

Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis.

30 July 2017

cites work

1 reference

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A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling

5 July 2018

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Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells

5 July 2018

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Treatment of pulmonary arterial hypertension

5 July 2018

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Cellular and molecular pathobiology of pulmonary arterial hypertension

5 July 2018

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Role of E2F and ERK1/2 in STI571-mediated smooth muscle cell growth arrest and cyclin A transcriptional repression.

5 July 2018

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Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy.

5 July 2018

1 reference

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Protein measurement with the Folin phenol reagent

5 July 2018

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NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR‐α‐dependent mechanism

5 July 2018

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Activation of p38 MAPK suppresses matrix metalloproteinase-1 gene expression induced by platelet-derived growth factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression

5 July 2018

1 reference

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Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors

5 July 2018

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Inhaled iloprost for severe pulmonary hypertension

5 July 2018

1 reference

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Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

5 July 2018

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Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia.

5 July 2018

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Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Sildenafil inhibits hypoxia-induced pulmonary hypertension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

PDGF-D, a new protease-activated growth factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Mechanism of action and in vivo role of platelet-derived growth factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Signal transduction via platelet-derived growth factor receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

5 July 2018

1 reference

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A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension

5 July 2018

1 reference

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The mitogen-activated protein kinase signal transduction pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Assessment of survival in patients with primary pulmonary hypertension: importance of cardiopulmonary exercise testing.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Platelet-derived growth factor expression in primary pulmonary hypertension: comparison of HIV seropositive and HIV seronegative patients

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236676

Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor

28 October 2018

1 reference

12 December 2020

Imbalance between Platelet Vascular Endothelial Growth Factor and Platelet-derived Growth Factor in Pulmonary Hypertension

1 reference

12 December 2020

Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells

1 reference

12 December 2020

Mechanical stretch augments PDGF receptor beta expression and protein tyrosine phosphorylation in pulmonary artery tissue and smooth muscle cells

1 reference

12 December 2020

Bosentan therapy for pulmonary arterial hypertension

1 reference

12 December 2020

Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus

1 reference

12 December 2020

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element

1 reference

12 December 2020

The predominant form of fibroblast growth factor receptor expressed by proliferating human arterial smooth muscle cells in culture is type I

1 reference

12 December 2020

Activation of PDGF receptor alpha in vascular smooth muscle cells by mechanical stress

1 reference

12 December 2020

Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148

1 reference

12 December 2020

Selective tyrosine kinase inhibitor for the platelet-derived growth factor receptor in vitro inhibits smooth muscle cell proliferation after reinjury of arterial intima in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI24838

1 reference

30 July 2017

1 reference

30 July 2017

1 reference