(Q34044755)

30 July 2017

title

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival (English)

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30 July 2017

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1 reference

11

Clemens Schafmayer

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Joschka Willemsen

Joschka Willemsen

9

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Bénédicte Manoury

Bénédicte Manoury

13

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Andrew G Bowie

Andrew G Bowie

16

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Marco Binder

Marco Binder

12

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Asta Försti

17

Asta Försti

1 reference

30 July 2017

14

Søren R Paludan

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30 July 2017

Hui Wang

1

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30 July 2017

Sinead M Flannery

2

1 reference

30 July 2017

Sabine Dickhöfer

3

1 reference

30 July 2017

Stefanie Huhn

4

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30 July 2017

Julie George

5

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30 July 2017

Andriy V Kubarenko

6

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30 July 2017

Jesus Lascorz

7

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30 July 2017

Melanie Bevier

8

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30 July 2017

Tica Pichulik

10

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30 July 2017

Marta Alarcon-Riquelme

15

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30 July 2017

Alexander N R Weber

18

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30 July 2017

language of work or name

English

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publication date

19 June 2014

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Journal of Biological Chemistry

30 July 2017

published in

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30 July 2017

volume

289

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30 July 2017

issue

33

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30 July 2017

page(s)

23123-23131

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Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Interleukin-6--a key regulator of colorectal cancer development.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

28 July 2018

Global cancer statistics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

What the Myddosome structure tells us about the initiation of innate immunity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Oncogenically active MYD88 mutations in human lymphoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

IRAK-4 inhibitors for inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Common vs. rare allele hypotheses for complex diseases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Toll-like receptor control of the adaptive immune responses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

The International HapMap Project

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

IRAK-M is a negative regulator of Toll-like receptor signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

Derivation of rules for comparative protein modeling from a database of protein structure alignments

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132810

The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

Natural Loss-of-function Mutation of Myeloid Differentiation Protein 88 Disrupts Its Ability to Form Myddosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

Polymorphisms in Toll-like receptor genes and risk of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

Development of TLR inhibitors for the treatment of autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

Pyogenic bacterial infections in humans with MyD88 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.492934

21 January 2018

Identifiers

DOI

10.1074/JBC.M113.492934

1 reference

30 July 2017

1 reference

30 July 2017

1 reference