(Q33943954)

30 July 2017

title

An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease (English)

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30 July 2017

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Mochizuki H

1

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30 July 2017

Hayakawa H

2

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30 July 2017

Migita M

3

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30 July 2017

Shibata M

4

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30 July 2017

Tanaka R

5

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30 July 2017

Suzuki A

6

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30 July 2017

Shimo-Nakanishi Y

7

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30 July 2017

Urabe T

8

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30 July 2017

Yamada M

9

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30 July 2017

Tamayose K

10

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30 July 2017

Shimada T

11

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30 July 2017

Miura M

12

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30 July 2017

Mizuno Y

13

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30 July 2017

language of work or name

English

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publication date

4 September 2001

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

98

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30 July 2017

issue

19

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30 July 2017

page(s)

10918-10923

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Apoptosis in neurodegenerative disorders

30 July 2017

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

From bench to clinic with apoptosis-based therapeutic agents

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Apoptosis in the nervous system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Energetics in the pathogenesis of neurodegenerative diseases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Mitochondrial control of cell death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Neuroprotection by the inhibition of apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Prevention of vertebrate neuronal death by the crmA gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Role of mitochondria in the etiology and pathogenesis of Parkinson's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Efficient selection for high-expression transfectants with a novel eukaryotic vector

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.191107398

A new strategy for large-scale preparation of high-titer recombinant adeno-associated virus vectors by using packaging cell lines and sulfonated cellulose column chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.191107398

Parkinson disease gene therapy moves toward the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.191107398

Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.191107398

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.191107398

Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58574

Inhibition of ICE slows ALS in mice

29 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.191107398

Histochemical detection of apoptosis in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.191107398

On the question of apoptosis in the parkinsonian substantia nigra

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.191107398

21 January 2018

Identifiers

DOI

10.1073/PNAS.191107398

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30 July 2017

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30 July 2017

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